Coptisine suppresses proliferation and inhibits metastasis in human pancreatic cancer PANC-1 cells
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Asian Natural Products Research"
DOI: 10.1080/10286020.2019.1585820
Abstract: Abstract The effects of coptisine against advanced stage of human pancreatic carcinoma PANC-1 cells was investigated in vitro. Coptisine (25–150 μM) treatment for 48 h caused dose-dependent cell growth inhibition by using CCK-8 assay. Additionally, coptisine was… read more here.
Keywords: panc cells; pancreatic cancer; metastasis; human pancreatic ... See more keywords
Coptisine from Coptis chinensis exerts diverse beneficial properties: A concise review
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.14725
Abstract: Coptisine is a natural small‐molecular compound extracted from Coptis chinensis (CC) with a history of using for thousands of years. This work aimed at summarizing coptisine's activity and providing advice for its clinical use. We… read more here.
Keywords: coptisine coptis; coptis chinensis; exerts diverse; chinensis exerts ... See more keywords
Pseudogene MSTO2P Interacts with miR-128-3p to Regulate Coptisine Sensitivity of Non-Small-Cell Lung Cancer (NSCLC) through TGF-β Signaling and VEGFC
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Oncology"
DOI: 10.1155/2022/9864411
Abstract: Background Coptisine has been widely used for treating a variety of cancer types. To date, whether pseudogene is implicated in coptisine resistance of NSCLC remains unknown. Methods We performed MTT to assess the cell viability… read more here.
Keywords: cell; msto2p; cell viability; coptisine ... See more keywords
Shang-Ke-Huang-Shui and coptisine alleviate osteoarthritis in the knee of monosodium iodoacetate-induced rats through inhibiting CXCR4 signaling.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of ethnopharmacology"
DOI: 10.2139/ssrn.4237126
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE Shang-Ke-Huang-Shui (SKHS) is a classic traditional Chinese medicine formula originally from the southern China city of Foshan. It has been widely used in the treatment of osteoarthritis (OA) but underlying molecular mechanisms remain… read more here.
Keywords: cxcr4 signaling; cxcr4 antagonist; cartilage; cxcr4 ... See more keywords
Coptisine Attenuates Diabetes—Associated Endothelial Dysfunction through Inhibition of Endoplasmic Reticulum Stress and Oxidative Stress
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DOI: 10.3390/molecules26144210
Abstract: Coptisine is the major bioactive protoberberine alkaloid found in Rhizoma Coptidis. Coptisine reduces inflammatory responses and improves glucose tolerance; nevertheless, whether coptisine has vasoprotective effect in diabetes is not fully characterized. Conduit arteries including aortas… read more here.
Keywords: stress oxidative; endoplasmic reticulum; oxidative stress; reticulum stress ... See more keywords
Coptisine Alleviates Imiquimod-Induced Psoriasis-like Skin Lesions and Anxiety-like Behavior in Mice
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27041412
Abstract: Psoriasis is a common inflammatory skin disorder, which can be associated with psychological disorders, such as anxiety and depression. This study investigated the efficacy and the mechanism of action of a natural compound coptisine using… read more here.
Keywords: psoriasis like; induced psoriasis; like skin; coptisine ... See more keywords
Coptisine attenuates post‑infectious IBS via Nrf2‑dependent inhibition of the NLPR3 inflammasome.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular medicine reports"
DOI: 10.3892/mmr.2022.12879
Abstract: Inhibition of the activation of the NLR family pyrin domain‑containing 3 (NLRP3) inflammasome has previously been reported to confer protection against post‑infectious irritable bowel syndrome (PI‑IBS). Coptisine, the second most abundant isoquinoline alkaloid in Coptis chinensis,… read more here.
Keywords: dependent inhibition; via nrf2; inhibition; post infectious ... See more keywords
Activation of the Nrf2/HO-1 signaling pathway contributes to the protective effects of coptisine against oxidative stress-induced DNA damage and apoptosis in HaCaT keratinocytes.
Sign Up to like & getrecommendations! Published in 2019 at "General physiology and biophysics"
DOI: 10.4149/gpb_2019014
Abstract: In this study, the protective effect of coptisine on the oxidative damage-mediated apoptosis was evaluated in cultured human HaCaT keratinocytes. The results demonstrate that preincubation of cells with coptisine prior to H2O2 stimulation resulted in… read more here.
Keywords: apoptosis; hacat keratinocytes; coptisine oxidative; h2o2 ... See more keywords