Flexible use of copula-type model for dose-finding in drug combination clinical trials.
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DOI: 10.1111/biom.13510
Abstract: Identification of the maximum tolerated dose combination (MTDC) of cancer drugs is an important objective in phase I oncology trials. Numerous dose-finding designs for drug combination have been proposed over the years. Copula-type models exhibit… read more here.
Keywords: combination; dose finding; copula type; type models ... See more keywords