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   Articles with "copy numbers" as a keyword



Spatio-temporal kinetics of patients' CAR-T cells in blood and serous cavity effusion: real-world clinical insights.

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recommendations! Published in 2025 at "Cellular oncology"

DOI: 10.1007/s13402-025-01120-2

Abstract: Chimeric antigen receptor (CAR) T cells have long been regarded as living drugs, those activation, diffusion, and expansion influence the clinical efficacy. Dynamic monitoring of CAR-T cells in vivo is crucial for understanding their biodistribution… read more here.

Keywords: effusion; car copy; car; copy numbers ... See more keywords

Is it Possible to Predict Non Sentinel Node Positivity on the Basis of mRNA Copy Numbers of CK19 Receptor in Breast Cancer?

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recommendations! Published in 2021 at "Clinical breast cancer"

DOI: 10.1016/j.clbc.2021.01.012

Abstract: AIMS To determine if there is any correlation between the number of positive non-sentinel lymph nodes (NSLN) and the mRNA copy numbers of cytokeratin 19 receptor on one step nucleic acid amplification (OSNA) in the… read more here.

Keywords: copy numbers; mrna copy; non sentinel; sentinel lymph ... See more keywords

Integrating protein copy numbers with interaction networks to quantify stoichiometry in clathrin-mediated endocytosis

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recommendations! Published in 2022 at "Scientific Reports"

DOI: 10.1038/s41598-022-09259-w

Abstract: Proteins that drive processes like clathrin-mediated endocytosis (CME) are expressed at copy numbers within a cell and across cell types varying from hundreds (e.g. auxilin) to millions (e.g. clathrin). These variations contain important information about… read more here.

Keywords: clathrin mediated; clathrin; copy numbers; network ... See more keywords

The analysis of the association between the copy numbers of survival motor neuron gene 2 and neuronal apoptosis inhibitory protein genes and the clinical phenotypes in 40 patients with spinal muscular atrophy

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recommendations! Published in 2020 at "Medicine"

DOI: 10.1097/md.0000000000018809

Abstract: Abstract In this article, the correlation between the copy number of survival motor neuron 2 (SMN2) gene, neuronal apoptosis inhibitory protein (NAIP), and the phenotype of spinal muscular atrophy patients were analyzed.Forty patients with spinal… read more here.

Keywords: spinal muscular; copy; gene; muscular atrophy ... See more keywords
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Association of AMY1A/AMY2A copy numbers and AMY1/AMY2 serum enzymatic activity with obesity in Mexican children

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recommendations! Published in 2020 at "Pediatric Obesity"

DOI: 10.1111/ijpo.12641

Abstract: Mexican children are characterized by a high‐starch intake diet and high prevalence of obesity. read more here.

Keywords: mexican children; copy numbers; association amy1a; amy2a copy ... See more keywords

Herpesviruses viral loads and levels of proinflammatory cytokines in apical periodontitis.

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recommendations! Published in 2018 at "Oral diseases"

DOI: 10.1111/odi.12829

Abstract: OBJECTIVES This study aimed to analyse Epstein-Barr virus (EBV) and human cytomegalovirus (HCMV) viral loads in symptomatic and asymptomatic apical periodontitis lesions, to determine levels of TNF-α, IL-1β and IL-6 in these lesions and to… read more here.

Keywords: copy numbers; apical periodontitis; proinflammatory cytokines; hcmv ... See more keywords

Analysis of the relative copy numbers of TP63, YAP1 and KMT2D genetic loci and EGFR expression in orthotopic patient-derived xenografts of cardioesophageal cancer in immunodeficient mice.

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recommendations! Published in 2021 at "Journal of Clinical Oncology"

DOI: 10.1200/jco.2021.39.15_suppl.e15033

Abstract: e15033 Background: Cardioesophageal cancer is a common tumor affecting the cardiac stomach and lower esophagus. Tumor heterogeneity is important, since it can cause the ineffectiveness of chemotherapy and radiotherapy due to individual characteristics of the… read more here.

Keywords: cancer; cardioesophageal cancer; egfr expression; copy numbers ... See more keywords

Stoichiometric balance of protein copy numbers is measurable and functionally significant in a protein-protein interaction network for yeast endocytosis

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recommendations! Published in 2018 at "PLoS Computational Biology"

DOI: 10.1371/journal.pcbi.1006022

Abstract: Stoichiometric balance, or dosage balance, implies that proteins that are subunits of obligate complexes (e.g. the ribosome) should have copy numbers expressed to match their stoichiometry in that complex. Establishing balance (or imbalance) is an… read more here.

Keywords: protein; protein copy; network; copy numbers ... See more keywords

Predictors of mortality in autoimmune disease patients with concurrent cytomegalovirus infections detected by quantitative real-time PCR

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recommendations! Published in 2017 at "PLoS ONE"

DOI: 10.1371/journal.pone.0181590

Abstract: Objective Cytomegaloviruses (CMV) can have a significant impact on the prognosis of immunocompromised patients. Unlike in the transplantation and AIDS fields, only a few studies on CMV infections have been published in the field of… read more here.

Keywords: cmv; copy numbers; autoimmune diseases; cmv infections ... See more keywords

Monitoring T-Cell Kinetics in the Early Recovery Period of Lung Transplantation Cases by Copy Number Levels of T-Cell Receptor Excision Circle

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recommendations! Published in 2023 at "In Vivo"

DOI: 10.21873/invivo.13081

Abstract: Abstract Background/Aim: Lung transplantation is a life-saving procedure for patients with end-stage lung diseases. T-Cell receptor excision circle (TREC) is circular DNA produced during T-cell receptor gene rearrangement in the thymus and indicates naive T-cell… read more here.

Keywords: lung; cell; copy numbers; lung transplantation ... See more keywords

The plasma virome in longitudinal samples from pregnant patients

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recommendations! Published in 2023 at "Frontiers in Cellular and Infection Microbiology"

DOI: 10.3389/fcimb.2023.1061230

Abstract: Introduction Nucleic acid from viruses is common in peripheral blood, even in asymptomatic individuals. How physiologic changes of pregnancy impact host-virus dynamics for acute, chronic, and latent viral infections is not well described. Previously we… read more here.

Keywords: pregnant patients; copy numbers; nucleic acid; samples pregnant ... See more keywords