Combinatorial Therapies After Spinal Cord Injury: How Can Biomaterials Help?
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DOI: 10.1002/adhm.201601130
Abstract: Traumatic spinal cord injury (SCI) results in an immediate loss of motor and sensory function below the injury site and is associated with a poor prognosis. The inhibitory environment that develops in response to the… read more here.
Keywords: combinatorial therapies; therapies spinal; combinatorial strategies; injury ... See more keywords
Silicate Nanoplatelets Promotes Neuronal Differentiation of Neural Stem Cells and Restoration of Spinal Cord Injury.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202203051
Abstract: Neural stem cell (NSC) transplantation has been suggested as a promising therapeutic strategy to replace lost neurons after spinal cord injury (SCI). However, the low survival rate and neuronal differentiation efficiency of implanted NSCs within… read more here.
Keywords: cord injury; neural stem; neuronal differentiation; spinal cord ... See more keywords
Exosomes‐Loaded Electroconductive Hydrogel Synergistically Promotes Tissue Repair after Spinal Cord Injury via Immunoregulation and Enhancement of Myelinated Axon Growth
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202105586
Abstract: Electroconductive hydrogels are very attractive candidates for accelerated spinal cord injury (SCI) repair because they match the electrical and mechanical properties of neural tissue. However, electroconductive hydrogel implantation can potentially aggravate inflammation, and hinder its… read more here.
Keywords: cord injury; electroconductive hydrogel; tissue; spinal cord ... See more keywords
Filter‐probe diffusion imaging improves spinal cord injury outcome prediction
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DOI: 10.1002/ana.25260
Abstract: Diffusion‐weighted imaging (DWI) is a powerful tool for investigating spinal cord injury (SCI), but has limited specificity for axonal damage, which is the most predictive feature of long‐term functional outcome. In this study, a technique… read more here.
Keywords: diffusion; outcome; filter probe; injury ... See more keywords
Combinatorial lentiviral gene delivery of pro‐oligodendrogenic factors for improving myelination of regenerating axons after spinal cord injury
Sign Up to like & getrecommendations! Published in 2019 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.26838
Abstract: Spinal cord injury (SCI) results in paralysis below the injury and strategies are being developed that support axonal regrowth, yet recovery lags, in part, because many axons are not remyelinated. Herein, we investigated strategies to… read more here.
Keywords: myelination; regenerating axons; myelination regenerating; cord injury ... See more keywords
Molecular and histologic outcomes following spinal cord injury in spiny mice, Acomys cahirinus
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DOI: 10.1002/cne.24836
Abstract: The spiny mouse (Acomys cahirinus) appears to be unique among mammals by showing little scarring or fibrosis after skin or muscle injury, but the Acomys response to spinal cord injury (SCI) is unknown. We tested… read more here.
Keywords: molecular histologic; injury; acomys cahirinus; acomys ... See more keywords
Effects of astaxanthin on sensory‐motor function in a compression model of spinal cord injury: Involvement of ERK and AKT signalling pathway
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Pain"
DOI: 10.1002/ejp.1342
Abstract: Spinal cord injury (SCI) causes continuous neurological deficits and major sensory‐motor impairments. There is no effective treatment to enhance sensory‐motor function following SCI. Thus, it is crucial to develop novel therapeutics for this particular patient… read more here.
Keywords: motor function; sensory motor; signalling pathway; motor ... See more keywords
LAR and PTPσ receptors are negative regulators of oligodendrogenesis and oligodendrocyte integrity in spinal cord injury
Sign Up to like & getrecommendations! Published in 2019 at "Glia"
DOI: 10.1002/glia.23533
Abstract: Following spinal cord injury (SCI), the population of mature oligodendrocytes undergoes substantial cell death; promoting their preservation and replacement is a viable strategy for preserving axonal integrity and white matter repair in the injured spinal… read more here.
Keywords: cord; lar ptp; ptp receptors; cord injury ... See more keywords
Myelin status and oligodendrocyte lineage cells over time after spinal cord injury: What do we know and what still needs to be unwrapped?
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DOI: 10.1002/glia.23702
Abstract: Spinal cord injury (SCI) affects over 17,000 individuals in the United States per year, resulting in sudden motor, sensory and autonomic impairments below the level of injury. These deficits may be due at least in… read more here.
Keywords: demyelination; oligodendrocyte lineage; injury; cord injury ... See more keywords
Temporary induction of hypoxic adaptations by preconditioning fails to enhance Schwann cell transplant survival after spinal cord injury
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DOI: 10.1002/glia.24302
Abstract: Hypoxic preconditioning is protective in multiple models of injury and disease, but whether it is beneficial for cells transplanted into sites of spinal cord injury (SCI) is largely unexplored. In this study, we analyzed whether… read more here.
Keywords: hypoxic adaptations; cell; cord injury; spinal cord ... See more keywords
Effects of Teriparatide and Vibration on Bone Mass and Bone Strength in People with Bone Loss and Spinal Cord Injury: A Randomized, Controlled Trial
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DOI: 10.1002/jbmr.3525
Abstract: Spinal cord injury (SCI) is associated with marked bone loss and an increased risk of fracture. We randomized 61 individuals with chronic SCI and low bone mass to receive either teriparatide 20 μg/d plus sham vibration… read more here.
Keywords: vibration; bone; bone mass; bone loss ... See more keywords