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   Articles with "cordycepin" as a keyword



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Cordycepin Attenuates IFN-γ-Induced Macrophage IP-10 and Mig Expressions by Inhibiting STAT1 Activity in CFA-Induced Inflammation Mice Model

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recommendations! Published in 2019 at "Inflammation"

DOI: 10.1007/s10753-019-01162-3

Abstract: Cordycepin, a natural derivative of adenosine, has been shown to exert pharmacological properties including anti-oxidation, antitumor, and immune regulation. It is reported that cordycepin is involved in the regulation of macrophage function. However, the effect… read more here.

Keywords: inflammation; cfa induced; model; ifn induced ... See more keywords
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Enhancing cordycepin production in liquid static cultivation of Cordyceps militaris by adding vegetable oils as the secondary carbon source.

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recommendations! Published in 2018 at "Bioresource technology"

DOI: 10.1016/j.biortech.2018.07.128

Abstract: This study evaluated different vegetable oils as the second carbon source in liquid static culture of Cordyceps militaris in terms of mycelial growth and cordycepin production. The maximum mycelial concentration and cordycepin production were observed… read more here.

Keywords: liquid static; carbon source; cordycepin production; vegetable oils ... See more keywords
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Cordycepin inhibits LPS‐induced acute lung injury by inhibiting inflammation and oxidative stress

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recommendations! Published in 2018 at "European Journal of Pharmacology"

DOI: 10.1016/j.ejphar.2017.10.029

Abstract: Abstract Acute lung injury (ALI) is a common severe clinical syndrome in intensive care unit. Inflammation has been reported to play a critical role in the development of ALI. Cordycepin, an active component isolated from… read more here.

Keywords: lps induced; acute lung; inflammation; lung injury ... See more keywords

Cordycepin (3'-deoxyadenosine) and pentostatin (deoxycoformycin) against Trypanosoma cruzi.

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recommendations! Published in 2019 at "Experimental parasitology"

DOI: 10.1016/j.exppara.2019.02.016

Abstract: The aim of this study was to evaluate in vitro the efficacy of cordycepin and pentostatin (alone or combined) against Trypanosoma cruzi, as well as the therapeutic efficiency of protocols of cordycepin and pentostatin combinations… read more here.

Keywords: cordycepin pentostatin; cordycepin deoxyadenosine; pentostatin; trypanosoma cruzi ... See more keywords
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Cordycepin mitigates MPTP‐induced Parkinson's disease through inhibiting TLR/NF‐&kgr;B signaling pathway

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recommendations! Published in 2019 at "Life Sciences"

DOI: 10.1016/j.lfs.2019.02.037

Abstract: Abstract Parkinson's disease (PD) is a neurodegenerative disease with movement disorder. PD is characterized by the loss of dopaminergic (DA) neurons in the substantia nigra. Cordycepin, a small molecule extracted from cordyceps sinensis, has neuroprotective,… read more here.

Keywords: kgr signaling; tlr kgr; disease; signaling pathway ... See more keywords
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Cordycepin sensitizes breast cancer cells toward irradiation through elevating ROS production involving Nrf2

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recommendations! Published in 2019 at "Toxicology and Applied Pharmacology"

DOI: 10.1016/j.taap.2018.12.006

Abstract: &NA; Radiation therapy toward malignancies is often ineffective owing to radioresistance of cancer cells. On the basis of anti‐tumor properties of cordycepin, we examined the effects of cordycepin on sensitizing breast cancer cells toward radiotherapy.… read more here.

Keywords: irradiation; breast cancer; cancer cells; cancer ... See more keywords
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Potent Inhibitory Activities of the Adenosine Analogue Cordycepin on SARS-CoV-2 Replication

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recommendations! Published in 2022 at "ACS Omega"

DOI: 10.1021/acsomega.1c05998

Abstract: Nucleoside analogues are among the most successful bioactive classes of druglike compounds in pharmaceutical chemistry as they are well-known for their numerous effective bioactivities in humans, especially as antiviral and anticancer agents. Coronavirus disease 2019… read more here.

Keywords: adenosine analogue; cov replication; sars cov; cordycepin ... See more keywords
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Increased Cordycepin Production in Yarrowia lipolytica Using Combinatorial Metabolic Engineering Strategies.

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recommendations! Published in 2023 at "ACS synthetic biology"

DOI: 10.1021/acssynbio.2c00570

Abstract: As the first nucleoside antibiotic discovered in fungi, cordycepin, with its various biological activities, has wide applications. At present, cordycepin is mainly obtained from the natural fruiting bodies of Cordyceps militaris. However, due to long… read more here.

Keywords: metabolic engineering; engineering strategies; production; lipolytica ... See more keywords
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Uncovering global metabolic response to cordycepin production in Cordyceps militaris through transcriptome and genome-scale network-driven analysis

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recommendations! Published in 2018 at "Scientific Reports"

DOI: 10.1038/s41598-018-27534-7

Abstract: The cellular metabolic adaptations of Cordyceps militaris have been progressively studied. In particular, the cordycepin pathway is of interest in medicinal applications. Even though the metabolic pathways for cordycepin production are known to be related… read more here.

Keywords: network driven; genome scale; driven analysis; analysis ... See more keywords
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Selective extraction of cordycepin from Cordyceps militaris – optimisation, kinetics and equilibrium studies

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recommendations! Published in 2020 at "Indian Chemical Engineer"

DOI: 10.1080/00194506.2020.1776163

Abstract: Cordycepin was separated successfully from Cordyceps militaris using extraction with a mixture of ethanol and water. Optimum temperature, composition of ethanol in water, solvent/solid ratio and pH... read more here.

Keywords: extraction cordycepin; selective extraction; cordyceps militaris; cordycepin cordyceps ... See more keywords
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Development of an Animal-Free Nitrogen Source for the Liquid Surface Culture of Cordyceps militaris.

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recommendations! Published in 2023 at "Letters in applied microbiology"

DOI: 10.1093/lambio/ovad053

Abstract: Cordyceps militaris is a medicinal mushroom in Asia in the twenty-first century, which cordycepin is a significant bioactive compound. This study investigated the effect of culture conditions and vegetable seed extract powder (VSEP) as a… read more here.

Keywords: culture; cordyceps militaris; animal free; free nitrogen ... See more keywords