Core battery safety pharmacology testing - An assessment of its utility in early drug development.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of pharmacological and toxicological methods"
DOI: 10.1016/j.vascn.2021.107055
Abstract: Requirements for safety pharmacology testing have been in place since the issue of initial regulatory guidance over 20 years ago. An evaluation of such testing, supporting first clinical entry of 105 small molecule drug candidates over… read more here.
Keywords: safety pharmacology; core battery; drug; pharmacology testing ... See more keywords
Simultaneous assessment of central nervous and respiratory systems using jacketed telemetry in socially-housed rats: Application of the "3Rs" principles in core battery safety pharmacology studies.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of pharmacological and toxicological methods"
DOI: 10.2139/ssrn.4357844
Abstract: Central nervous (CNS) and respiratory systems are routinely investigated in safety pharmacology core battery studies. For small molecules, the assessment of both vital organ systems is frequently done in rats in two distinct studies. With… read more here.
Keywords: pharmacology; respiratory; core battery; safety pharmacology ... See more keywords