Recognition of Core-Fucosylated Glycopeptides Based on the Y1+Fuc/Y1 Ratio in Low-Energy HCD Spectra.
Sign Up to like & getrecommendations! Published in 2022 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.2c03182
Abstract: Accurate identification of core fucosylation on N-glycopeptides remains challenging due to fucose migration during mass spectrometry analysis. Here, we introduce a simple and straightforward method for core-fucosylated glycopeptide recognition based on the relative intensities of… read more here.
Keywords: core; energy; ratio low; core fucosylated ... See more keywords
Abstract P5-01-23: Linking Spatial Distribution of Core Fucosylated N-Glycans to Triple Negative Breast Cancer Outcomes
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DOI: 10.1158/1557-3265.sabcs24-p5-01-23
Abstract: Triple Negative Breast Cancer (TNBC) is an aggressive breast cancer subtype with poor prognosis, partly due to its heterogenous molecular profile. Unlike other breast cancer subtypes, targeted therapies for TNBC are lacking, highlighting an urgent… read more here.
Keywords: cancer; breast cancer; breast; fucosylated glycans ... See more keywords
FUT8: from biochemistry to synthesis of core-fucosylated N-glycans
Sign Up to like & getrecommendations! Published in 2017 at "Pure and Applied Chemistry"
DOI: 10.1515/pac-2016-0923
Abstract: Abstract Glycosylation is a major posttranslational modification of proteins. Modification in structure on N-glycans leads to many diseases. One of such modifications is core α-1,6 fucosylation, which is only found in eukaryotes. For this reason,… read more here.
Keywords: biochemistry; core fucosylated; synthesis core; fucosylated glycans ... See more keywords