Common Disease Is More Complex Than Implied by the Core Gene Omnigenic Model
Sign Up to like & getrecommendations! Published in 2018 at "Cell"
DOI: 10.1016/j.cell.2018.05.051
Abstract: The evidence that most adult-onset common diseases have a polygenic genetic architecture fully consistent with robust biological systems supported by multiple back-up mechanisms is now overwhelming. In this context, we consider the recent "omnigenic" or… read more here.
Keywords: common disease; model; disease complex; core genes ... See more keywords
Core genes in diverse dinoflagellate lineages include a wealth of conserved dark genes with unknown functions
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-35620-z
Abstract: Dinoflagellates are a diverse group of unicellular primary producers and grazers that exhibit some of the most remarkable features known among eukaryotes. These include gigabase-sized nuclear genomes, permanently condensed chromosomes and highly reduced organelle DNA.… read more here.
Keywords: diverse dinoflagellate; genes diverse; dinoflagellate lineages; lineages include ... See more keywords
Relationship between osteoporosis and Cushing syndrome based on bioinformatics
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DOI: 10.1097/md.0000000000031283
Abstract: Background: Many clinical studies have reported a relatively high incidence of osteoporosis and fragility fractures in patients with Cushing syndrome (CS). However, few papers have investigated osteoporosis and CS in terms of pathogenesis, so this… read more here.
Keywords: osteoporosis cushing; relationship; core genes; cushing syndrome ... See more keywords
Shared properties of gene transfer agent and core genes revealed by comparative genomics of Alphaproteobacteria
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DOI: 10.1099/mgen.0.000890
Abstract: Gene transfer agents (GTAs) are phage-like particles that transfer pieces of cellular genomic DNA to other cells. Homologues of the Rhodobacter capsulatus GTA (RcGTA) structural genes are widely distributed in the Alphaproteobacteria and particularly well… read more here.
Keywords: gene transfer; core genes; shared properties; gene ... See more keywords
UFCG: database of universal fungal core genes and pipeline for genome-wide phylogenetic analysis of fungi
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1101/2022.08.16.504087
Abstract: In phylogenomics the evolutionary relationship of organisms is studied by their genomic information. A common approach to phylogenomics is to extract related genes from each organism, build a multiple sequence alignment and then reconstruct evolution… read more here.
Keywords: pipeline; analysis; ufcg database; core genes ... See more keywords
The microRNA pathway core genes are indispensable for development and reproduction in the brown planthopper, Nilaparvata lugens.
Sign Up to like & getrecommendations! Published in 2023 at "Insect molecular biology"
DOI: 10.1111/imb.12848
Abstract: MicroRNAs (miRNAs) are small single-stranded non-coding RNAs involved in a variety of cellular events by regulating gene expression at the post-transcriptional level. Several core genes in miRNA biogenesis have been reported to participate in a… read more here.
Keywords: core; development; expression; pathway core ... See more keywords
Identification of Potential Key Genes and Prognostic Biomarkers of Lung Cancer Based on Bioinformatics
Sign Up to like & getrecommendations! Published in 2023 at "BioMed Research International"
DOI: 10.1155/2023/2152432
Abstract: Objective To analyze and identify the core genes related to the expression and prognosis of lung cancer including lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC) by bioinformatics technology, with the aim of providing… read more here.
Keywords: lung cancer; core genes; cancer; expression ... See more keywords
Identification of cardiomyopathy-related core genes through human metabolic networks and expression data
Sign Up to like & getrecommendations! Published in 2022 at "BMC Genomics"
DOI: 10.1186/s12864-021-08271-0
Abstract: Background Cardiomyopathy is a complex type of myocardial disease, and its incidence has increased significantly in recent years. Dilated cardiomyopathy (DCM) and ischemic cardiomyopathy (ICM) are two common and indistinguishable types of cardiomyopathy. Results Here,… read more here.
Keywords: related core; human metabolic; core genes; cardiomyopathy related ... See more keywords
Multi-omics analysis of genomics, epigenomics and transcriptomics for molecular subtypes and core genes for lung adenocarcinoma
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DOI: 10.1186/s12885-021-07888-4
Abstract: Background Lung adenocarcinoma (LUAD) is the most frequently diagnosed histological subtype of lung cancer. Our purpose was to explore molecular subtypes and core genes for LUAD using multi-omics analysis. Methods Methylation, transcriptome, copy number variation… read more here.
Keywords: lung adenocarcinoma; multi omics; analysis; molecular subtypes ... See more keywords
Constrained evolution of overlapping genes in viral host adaptation: Acquisition of glycosylation motifs in hepadnaviral precore/core genes
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Pathogens"
DOI: 10.1371/journal.ppat.1010739
Abstract: Hepadnaviruses use extensively overlapping genes to expand their coding capacity, especially the precore/core genes encode the precore and core proteins with mostly identical sequences but distinct functions. The precore protein of the woodchuck hepatitis virus… read more here.
Keywords: core genes; overlapping genes; glycosylation; precore core ... See more keywords
Biomarker identification of immune-related genes in pheochromocytoma and paraganglioma
Sign Up to like & getrecommendations! Published in 2023 at "Translational Andrology and Urology"
DOI: 10.21037/tau-22-800
Abstract: Background Although we have a good understanding of the diagnosis and treatment of pheochromocytoma and paraganglioma (PPGL), the underlying pathogenesis and molecular pathways of PPGL need to be further studied. This study aimed to use… read more here.
Keywords: immune related; pheochromocytoma paraganglioma; ppgl; core genes ... See more keywords