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   Articles with "core genes" as a keyword



Common Disease Is More Complex Than Implied by the Core Gene Omnigenic Model

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recommendations! Published in 2018 at "Cell"

DOI: 10.1016/j.cell.2018.05.051

Abstract: The evidence that most adult-onset common diseases have a polygenic genetic architecture fully consistent with robust biological systems supported by multiple back-up mechanisms is now overwhelming. In this context, we consider the recent "omnigenic" or… read more here.

Keywords: common disease; model; disease complex; core genes ... See more keywords

Core genes in diverse dinoflagellate lineages include a wealth of conserved dark genes with unknown functions

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recommendations! Published in 2018 at "Scientific Reports"

DOI: 10.1038/s41598-018-35620-z

Abstract: Dinoflagellates are a diverse group of unicellular primary producers and grazers that exhibit some of the most remarkable features known among eukaryotes. These include gigabase-sized nuclear genomes, permanently condensed chromosomes and highly reduced organelle DNA.… read more here.

Keywords: diverse dinoflagellate; genes diverse; dinoflagellate lineages; lineages include ... See more keywords

Relationship between osteoporosis and Cushing syndrome based on bioinformatics

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recommendations! Published in 2022 at "Medicine"

DOI: 10.1097/md.0000000000031283

Abstract: Background: Many clinical studies have reported a relatively high incidence of osteoporosis and fragility fractures in patients with Cushing syndrome (CS). However, few papers have investigated osteoporosis and CS in terms of pathogenesis, so this… read more here.

Keywords: osteoporosis cushing; relationship; core genes; cushing syndrome ... See more keywords

Identification of core genes shared by ischemic stroke and myocardial infarction using an integrated approach

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recommendations! Published in 2024 at "Medicine"

DOI: 10.1097/md.0000000000038877

Abstract: Background: Both ischemic stroke (IS) and myocardial infarction (MI) are caused by vascular occlusion that results in ischemia. While there may be similarities in their mechanisms, the potential relationship between these 2 diseases has not… read more here.

Keywords: ischemic stroke; stroke myocardial; analysis; gene ... See more keywords

Shared properties of gene transfer agent and core genes revealed by comparative genomics of Alphaproteobacteria

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recommendations! Published in 2022 at "Microbial Genomics"

DOI: 10.1099/mgen.0.000890

Abstract: Gene transfer agents (GTAs) are phage-like particles that transfer pieces of cellular genomic DNA to other cells. Homologues of the Rhodobacter capsulatus GTA (RcGTA) structural genes are widely distributed in the Alphaproteobacteria and particularly well… read more here.

Keywords: gene transfer; core genes; shared properties; gene ... See more keywords

UFCG: database of universal fungal core genes and pipeline for genome-wide phylogenetic analysis of fungi

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recommendations! Published in 2022 at "Nucleic Acids Research"

DOI: 10.1101/2022.08.16.504087

Abstract: In phylogenomics the evolutionary relationship of organisms is studied by their genomic information. A common approach to phylogenomics is to extract related genes from each organism, build a multiple sequence alignment and then reconstruct evolution… read more here.

Keywords: pipeline; analysis; ufcg database; core genes ... See more keywords

The microRNA pathway core genes are indispensable for development and reproduction in the brown planthopper, Nilaparvata lugens.

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recommendations! Published in 2023 at "Insect molecular biology"

DOI: 10.1111/imb.12848

Abstract: MicroRNAs (miRNAs) are small single-stranded non-coding RNAs involved in a variety of cellular events by regulating gene expression at the post-transcriptional level. Several core genes in miRNA biogenesis have been reported to participate in a… read more here.

Keywords: core; development; expression; pathway core ... See more keywords

Identification of Potential Key Genes and Prognostic Biomarkers of Lung Cancer Based on Bioinformatics

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recommendations! Published in 2023 at "BioMed Research International"

DOI: 10.1155/2023/2152432

Abstract: Objective To analyze and identify the core genes related to the expression and prognosis of lung cancer including lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC) by bioinformatics technology, with the aim of providing… read more here.

Keywords: lung cancer; core genes; cancer; expression ... See more keywords

Identification of cardiomyopathy-related core genes through human metabolic networks and expression data

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recommendations! Published in 2022 at "BMC Genomics"

DOI: 10.1186/s12864-021-08271-0

Abstract: Background Cardiomyopathy is a complex type of myocardial disease, and its incidence has increased significantly in recent years. Dilated cardiomyopathy (DCM) and ischemic cardiomyopathy (ICM) are two common and indistinguishable types of cardiomyopathy. Results Here,… read more here.

Keywords: related core; human metabolic; core genes; cardiomyopathy related ... See more keywords
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Multi-omics analysis of genomics, epigenomics and transcriptomics for molecular subtypes and core genes for lung adenocarcinoma

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recommendations! Published in 2021 at "BMC Cancer"

DOI: 10.1186/s12885-021-07888-4

Abstract: Background Lung adenocarcinoma (LUAD) is the most frequently diagnosed histological subtype of lung cancer. Our purpose was to explore molecular subtypes and core genes for LUAD using multi-omics analysis. Methods Methylation, transcriptome, copy number variation… read more here.

Keywords: lung adenocarcinoma; multi omics; analysis; molecular subtypes ... See more keywords

Integrative transcriptomic analysis reveals cross-species conserved core genes and pathways in alveolar macrophages during ALI/ARDS

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recommendations! Published in 2025 at "BMC Pulmonary Medicine"

DOI: 10.1186/s12890-025-03928-y

Abstract: acute respiratory distress syndrome (ARDS) is a severe pulmonary condition characterized by alveolar-capillary damage and refractory hypoxemia. Alveolar macrophages (AMs) play a crucial role in regulating inflammation and repair processes during acute lung injury (ALI)/ARDS.… read more here.

Keywords: analysis; ali ards; alveolar macrophages; cross species ... See more keywords