Robust oil-core nanocapsules with hyaluronate-based shells as promising nanovehicles for lipophilic compounds.
Sign Up to like & getrecommendations! Published in 2017 at "Nanoscale"
DOI: 10.1039/c7nr05851a
Abstract: The design of nanodelivery systems has been recently considered as a solution to the major challenge in pharmaceutical research - poor bioavailability of lipophilic drugs. Nanocapsules with liquid oil cores and shells based on amphiphilic… read more here.
Keywords: core nanocapsules; oil core; robust oil; hyaluronate based ... See more keywords
Artemether-loaded polymeric lipid-core nanocapsules reduce cell viability and alter the antioxidant status of U-87 MG cells
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutical Development and Technology"
DOI: 10.1080/10837450.2022.2128819
Abstract: Abstract Glioblastomas are tumors that present a high mortality rate. Artemether (ART) is a lactone with antitumor properties, demonstrating low bioavailability and water solubility. In the present study, we developed lipid-core nanocapsules (LNC) containing pequi… read more here.
Keywords: antioxidant status; core nanocapsules; viability; lipid core ... See more keywords
Robust liquid-core nanocapsules as biocompatible and precise ratiometric fluorescent thermometers for living cells.
Sign Up to like & getrecommendations! Published in 2020 at "Nanotechnology"
DOI: 10.1088/1361-6528/ab95b6
Abstract: Intracellular thermometry with favorable biocompatibility and precision is essential for insight into the temperature-related cellular events. Here, liquid-core nanocapsules as ratiometric fluorescent thermometers (LCN-RFTs) are prepared by encapsulating thermosensitive organic fluorophores (N, N'-di(2-ethylhexyl)-3,4,9,10-perylene tetracarboxylic diimide,… read more here.
Keywords: core nanocapsules; intracellular thermometry; ratiometric fluorescent; liquid core ... See more keywords
Melatonin-loaded lipid-core nanocapsules protect against lipid peroxidation caused by paraquat through increased SOD expression in Caenorhabditis elegans
Sign Up to like & getrecommendations! Published in 2019 at "BMC Pharmacology & Toxicology"
DOI: 10.1186/s40360-019-0352-4
Abstract: Background Melatonin has been described in the literature as a potent antioxidant. However, melatonin presents variable, low bioavailability and a short half-life. The use of polymeric nanoparticulated systems has been proposed for controlled release. Thus,… read more here.
Keywords: core nanocapsules; lipid peroxidation; mel lnc; lipid core ... See more keywords
Arginylglycylaspartic Acid-Surface-Functionalized Doxorubicin-Loaded Lipid-Core Nanocapsules as a Strategy to Target Alpha(V) Beta(3) Integrin Expressed on Tumor Cells
Sign Up to like & getrecommendations! Published in 2017 at "Nanomaterials"
DOI: 10.3390/nano8010002
Abstract: Doxorubicin (Dox) clinical use is limited by dose-related cardiomyopathy, becoming more prevalent with increasing cumulative doses. Previously, we developed Dox-loaded lipid-core nanocapsules (Dox-LNC) and, in this study, we hypothesized that self-assembling and interfacial reactions could… read more here.
Keywords: core nanocapsules; rgd mcmn; lipid core; arginylglycylaspartic acid ... See more keywords