Eukaryotic core promoters and the functional basis of transcription initiation
Sign Up to like & getrecommendations! Published in 2018 at "Nature Reviews Molecular Cell Biology"
DOI: 10.1038/s41580-018-0028-8
Abstract: RNA polymerase II (Pol II) core promoters are specialized DNA sequences at transcription start sites of protein-coding and non-coding genes that support the assembly of the transcription machinery and transcription initiation. They enable the highly… read more here.
Keywords: transcription; gene; transcription initiation; core promoters ... See more keywords
Unraveling the start element and regulatory divergence of core promoters across the domain bacteria
Sign Up to like & getrecommendations! Published in 2025 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkaf1310
Abstract: Core promoters comprise multiple elements whose interaction with RNA polymerase initiates transcription. Despite decades of research, substantial sequence and length variation of promoter elements has hindered efforts to elucidate their function and the evolutionary diversity… read more here.
Keywords: promoter; element; regulatory divergence; core promoters ... See more keywords
High-throughput functional analysis of lncRNA core promoters elucidates rules governing tissue specificity.
Sign Up to like & getrecommendations! Published in 2019 at "Genome research"
DOI: 10.1101/gr.242222.118
Abstract: Transcription initiates at both coding and noncoding genomic elements, including mRNA and long noncoding RNA (lncRNA) core promoters and enhancer RNAs (eRNAs). However, each class has a different expression profile with lncRNAs and eRNAs being… read more here.
Keywords: lncrna core; tissue specificity; tissue; core promoters ... See more keywords
Pervasive and dynamic transcription initiation in Saccharomyces cerevisiae.
Sign Up to like & getrecommendations! Published in 2019 at "Genome research"
DOI: 10.1101/gr.245456.118
Abstract: Transcription initiation is finely regulated to ensure proper expression and function of genes. The regulated transcription initiation in response to various environmental stimuli in a classic model organism Saccharomyces cerevisiae has not been systematically investigated.… read more here.
Keywords: transcription; saccharomyces cerevisiae; transcription initiation; core promoters ... See more keywords
Selective translational usage of TSS and core promoters revealed by translatome sequencing
Sign Up to like & getrecommendations! Published in 2019 at "BMC Genomics"
DOI: 10.1186/s12864-019-5650-0
Abstract: BackgroundIn mammals, fine-tuned regulation of gene expression leads to transcription initiation from diverse transcription start sites (TSSs) and multiple core promoters. Although polysome association is a critical step in translation, whether polysome selectively uses TSSs… read more here.
Keywords: translation; core promoters; usage; transcription initiation ... See more keywords