Hepatitis C virus core protein interacts with cellular metastasis suppressor Nm23-H1 and promotes cell migration and invasion
Sign Up to like & getrecommendations! Published in 2019 at "Archives of Virology"
DOI: 10.1007/s00705-019-04151-x
Abstract: Hepatitis C virus (HCV) is the major etiological agent of hepatocellular carcinoma (HCC), which is the fourth most common cause of cancer-related deaths worldwide and second in terms of deaths of males (Bray et al.… read more here.
Keywords: protein; core protein; hcv; metastasis ... See more keywords
Deep sequencing identifies hepatitis B virus core protein signatures in chronic hepatitis B patients
Sign Up to like & getrecommendations! Published in 2018 at "Antiviral Research"
DOI: 10.1016/j.antiviral.2018.08.009
Abstract: Background We aimed to identify HBc amino acid differences between subgroups of chronic hepatitis B (CHB) patients. Methods Deep sequencing of HBc was performed in samples of 89 CHB patients (42 HBeAg positive, 47 HBeAg… read more here.
Keywords: negative patients; amino acid; response; core protein ... See more keywords
The immunogenicity in mice of hepatitis C virus core protein delivered as DNA is modulated by its capacity to promote ROS production and activate Nrf2/ARE pathway
Sign Up to like & getrecommendations! Published in 2018 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2018.10.253
Abstract: Hepatitis C virus (HCV) core protein is an attractive target for HCV vaccine, however little progress was achieved in trials. We aimed to delineate the factors restricting immunogenicity of HCV core, and to improve its… read more here.
Keywords: protein; core protein; ros production; hcv core ... See more keywords
Ripply2 transforms Xbra to a repressor in Xenopus gastrula embryo
Sign Up to like & getrecommendations! Published in 2017 at "Mechanisms of Development"
DOI: 10.1016/j.mod.2017.04.201
Abstract: and negative interactions can occur between core protein complexes, and are necessary to establish their cellular asymmetric localisation. However, the roles of individual core proteins in mediating such interactions are not well understood. Here we… read more here.
Keywords: protein; negative interactions; core protein; cell ... See more keywords
Assembly of Capsids from Hepatitis B Virus Core Protein Progresses through Highly Populated Intermediates in the Presence and Absence of RNA
Sign Up to like & getrecommendations! Published in 2020 at "ACS Nano"
DOI: 10.1021/acsnano.0c03569
Abstract: The genetic material of viruses is protected by protein shells that are assembled from a large number of subunits in a process that is efficient and robust. Many of the mechanistic details underpinning efficient assembly… read more here.
Keywords: protein; rna; core protein; hepatitis virus ... See more keywords
Cryo-EM structure and oligomerization of the human planar cell polarity core protein Vangl1
Sign Up to like & getrecommendations! Published in 2025 at "Nature Communications"
DOI: 10.1038/s41467-024-55397-2
Abstract: Vangl is a planar cell polarity (PCP) core protein essential for aligned cell orientation along the epithelial plane perpendicular to the apical-basal direction, which is important for tissue morphogenesis, development and collective cell behavior. Mutations… read more here.
Keywords: cell; cell polarity; planar cell; core protein ... See more keywords
Hepatitis C virus core protein increases Snail expression and induces epithelial–mesenchymal transition through the signal transducer and activator of transcription 3 pathway in hepatoma cells
Sign Up to like & getrecommendations! Published in 2017 at "Hepatology Research"
DOI: 10.1111/hepr.12771
Abstract: Aberrant expression of Snail, a mediator of epithelial–mesenchymal transition (EMT), is crucial for cancer invasiveness and metastasis. Although hepatitis C virus (HCV) core protein has been implicated in hepatocarcinogenesis, the relationship between HCV core and… read more here.
Keywords: mesenchymal transition; core protein; epithelial mesenchymal; expression ... See more keywords
HBV Core Protein Is in Flux between Cytoplasmic, Nuclear, and Nucleolar Compartments
Sign Up to like & getrecommendations! Published in 2021 at "mBio"
DOI: 10.1128/mbio.03514-20
Abstract: HBV is an endemic virus. More than 250 million people suffer from chronic HBV infection and about 800,000 die from HBV-associated disease each year. ABSTRACT Hepatitis B virus (HBV) core protein (Cp) can be found… read more here.
Keywords: hbv; virus; hbv core; core protein ... See more keywords
HBV core protein allosteric modulators differentially alter cccDNA biosynthesis from de novo infection and intracellular amplification pathways
Sign Up to like & getrecommendations! Published in 2017 at "PLoS Pathogens"
DOI: 10.1371/journal.ppat.1006658
Abstract: Hepatitis B virus (HBV) core protein assembles viral pre-genomic (pg) RNA and DNA polymerase into nucleocapsids for reverse transcriptional DNA replication to take place. Several chemotypes of small molecules, including heteroaryldihydropyrimidines (HAPs) and sulfamoylbenzamides (SBAs),… read more here.
Keywords: protein; core protein; novo infection; dna ... See more keywords
Discovery of bimodal hepatitis B virus ribonuclease H and capsid assembly inhibitors
Sign Up to like & getrecommendations! Published in 2025 at "PLOS Pathogens"
DOI: 10.1371/journal.ppat.1012920
Abstract: Hepatitis B virus (HBV) ribonuclease H (RNaseH) inhibitors are a potent class of antivirals that prevent degradation of the viral pregenomic RNA during reverse transcription and block formation of mature HBV DNAs. Development of HBV… read more here.
Keywords: hbv; core protein; capsid; capsid assembly ... See more keywords
Identification of the Interaction between Minichromosome Maintenance Proteins and the Core Protein of Hepatitis B Virus
Sign Up to like & getrecommendations! Published in 2023 at "Current Issues in Molecular Biology"
DOI: 10.3390/cimb45010050
Abstract: Chronic HBV infection is a major cause of cirrhosis and hepatocellular carcinoma. Finding host factors involved in the viral life cycle and elucidating their mechanisms is essential for developing innovative strategies for treating HBV. The… read more here.
Keywords: identification interaction; host factors; protein; core protein ... See more keywords