Computational fragment-based design of Wee1 kinase inhibitors with tricyclic core scaffolds
Sign Up to like & getrecommendations! Published in 2018 at "Structural Chemistry"
DOI: 10.1007/s11224-018-1176-3
Abstract: Wee1 is cell cycle protein comprising a kinase domain and is a validated cancer target. We have designed molecules with variable tricyclic core scaffolds [6-6-5] system and extended them based on the chemical space available… read more here.
Keywords: core scaffolds; kinase; wee1 kinase; tricyclic core ... See more keywords
Carboxylic Acid Isostere Derivatives of Hydroxypyridinones as Core Scaffolds for Influenza Endonuclease Inhibitors
Sign Up to like & getrecommendations! Published in 2022 at "ACS Medicinal Chemistry Letters"
DOI: 10.1021/acsmedchemlett.2c00434
Abstract: Among the most important influenza virus targets is the RNA-dependent RNA polymerase acidic N-terminal (PAN) endonuclease, which is a critical component of the viral replication machinery. To inhibit the activity of this metalloenzyme, small-molecule inhibitors… read more here.
Keywords: carboxylic acid; derivatives hydroxypyridinones; core scaffolds; hydroxypyridinones core ... See more keywords