Tyrosine 121 moves revealing a ligandable pocket that couples catalysis to ATP-binding in serine racemase.
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DOI: 10.1038/s42003-022-03264-5
Abstract: Human serine racemase (hSR) catalyses racemisation of L-serine to D-serine, the latter of which is a co-agonist of the NMDA subtype of glutamate receptors that are important in synaptic plasticity, learning and memory. In a… read more here.
Keywords: pocket; core small; ligandable pocket; serine ... See more keywords