In silico analysis and experimental validation to exhibit anti-nasopharyngeal carcinoma effects of plumbagin, an anti-cancer compound.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the science of food and agriculture"
DOI: 10.1002/jsfa.11900
Abstract: BACKGROUND Nasopharyngeal carcinoma (NPC) is publicly known as a malignant tumor. Our previous study reports plumbagin exhibiting potent anti-cancer actions. Howbeit, more mechanical details of plumbagin against NPC remain untapped. Here, our study aimed to… read more here.
Keywords: nasopharyngeal carcinoma; experimental validation; validation; silico analysis ... See more keywords
Exploring the potential mechanisms of acetyl tributyl citrate exposure on osteoarthritis based on novel network toxicology
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DOI: 10.1038/s41598-025-11178-5
Abstract: The toxic side effects of acetyl tributyl citrate (ATBC) on humans are concerning, but studies related to its effects on osteoarthritis (OA) are lacking. Therefore, this study aimed to explore the potential targets and mechanisms… read more here.
Keywords: network toxicology; acetyl tributyl; network; toxicology ... See more keywords
Development and Validation of the Diagnostic Model of 7 Gene in Endometriosis.
Sign Up to like & getrecommendations! Published in 2024 at "Current medicinal chemistry"
DOI: 10.2174/0109298673283426231220100011
Abstract: AIMS To explore the diagnostic biomarkers for diagnosing endometriosis. BACKGROUND Endometriosis is a benign, progressive, estrogen-dependent gynecological disorder that has highly variant prevalence. Therefore, it is essential to develop reliable diagnostic biomarkers for endometriosis diagnosis.… read more here.
Keywords: analysis; endometriosis; diagnostic model; gene ... See more keywords
Network Pharmacological Study on Mechanism of the Therapeutic Effect of Modified Duhuo Jisheng Decoction in Osteoporosis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2022.860649
Abstract: Background Modified Duhuo Jisheng Decoction (MDHJSD) is a traditional Chinese medicine prescription for the treatment of osteoporosis (OP), but its mechanism of action has not yet been clarified. This study aims to explore the mechanism… read more here.
Keywords: pharmacology; modified duhuo; mechanism; core targets ... See more keywords
Investigations of nitazoxanide molecular targets and pathways for the treatment of hepatocellular carcinoma using network pharmacology and molecular docking
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.968148
Abstract: Nitazoxanide has been investigated for colorectal cancer and breast cancer. However, its molecular targets and pathways have not yet been explored for hepatocellular carcinoma (HCC) treatment. Utilizing a network pharmacology approach, nitazoxanide’s potential targets and… read more here.
Keywords: network; targets pathways; pharmacology; core targets ... See more keywords
The mechanism of vitamin D3 in preventing colorectal cancer through network pharmacology
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2023.1192210
Abstract: Objective: Colorectal cancer (CRC) is a common cancer that cannot be detected at an early stage and is a major challenge in oncology research. Studies have shown that vitamin D3 has some anti-cancer and preventive… read more here.
Keywords: pharmacology; colorectal cancer; core targets; network pharmacology ... See more keywords
Therapeutic targets and signaling mechanisms of dasatinib activity against radiation skin ulcer
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Public Health"
DOI: 10.3389/fpubh.2022.1031038
Abstract: Objective To reveal the potential targets and signaling pathways of dasatinib in the treatment of radiation ulcers through network pharmacology and molecular docking technology. Methods Pathological targets of radiation ulcers were screened using GeneCards database.… read more here.
Keywords: radiation ulcers; radiation; core targets; dasatinib ... See more keywords
Integrative Analysis of Pharmacology and Transcriptomics Predicts Resveratrol Will Ameliorate Microplastics-Induced Lung Damage by Targeting Ccl2 and Esr1
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DOI: 10.3390/toxics12120910
Abstract: Background: Microplastics (MPs) are ubiquitous on earth, posing a growing threat to human health. Previous studies have shown that the lung is a primary organ for MPs exposure. Resveratrol (RES) is a common dietary polyphenol… read more here.
Keywords: induced lung; analysis; pharmacology; lung damage ... See more keywords