In silico analysis and experimental validation to exhibit anti-nasopharyngeal carcinoma effects of plumbagin, an anti-cancer compound.
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DOI: 10.1002/jsfa.11900
Abstract: BACKGROUND Nasopharyngeal carcinoma (NPC) is publicly known as a malignant tumor. Our previous study reports plumbagin exhibiting potent anti-cancer actions. Howbeit, more mechanical details of plumbagin against NPC remain untapped. Here, our study aimed to… read more here.
Keywords: nasopharyngeal carcinoma; experimental validation; validation; silico analysis ... See more keywords
Network Pharmacological Study on Mechanism of the Therapeutic Effect of Modified Duhuo Jisheng Decoction in Osteoporosis
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DOI: 10.3389/fendo.2022.860649
Abstract: Background Modified Duhuo Jisheng Decoction (MDHJSD) is a traditional Chinese medicine prescription for the treatment of osteoporosis (OP), but its mechanism of action has not yet been clarified. This study aims to explore the mechanism… read more here.
Keywords: pharmacology; modified duhuo; mechanism; core targets ... See more keywords
Investigations of nitazoxanide molecular targets and pathways for the treatment of hepatocellular carcinoma using network pharmacology and molecular docking
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DOI: 10.3389/fphar.2022.968148
Abstract: Nitazoxanide has been investigated for colorectal cancer and breast cancer. However, its molecular targets and pathways have not yet been explored for hepatocellular carcinoma (HCC) treatment. Utilizing a network pharmacology approach, nitazoxanide’s potential targets and… read more here.
Keywords: network; targets pathways; pharmacology; core targets ... See more keywords
The mechanism of vitamin D3 in preventing colorectal cancer through network pharmacology
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DOI: 10.3389/fphar.2023.1192210
Abstract: Objective: Colorectal cancer (CRC) is a common cancer that cannot be detected at an early stage and is a major challenge in oncology research. Studies have shown that vitamin D3 has some anti-cancer and preventive… read more here.
Keywords: pharmacology; colorectal cancer; core targets; network pharmacology ... See more keywords
Therapeutic targets and signaling mechanisms of dasatinib activity against radiation skin ulcer
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DOI: 10.3389/fpubh.2022.1031038
Abstract: Objective To reveal the potential targets and signaling pathways of dasatinib in the treatment of radiation ulcers through network pharmacology and molecular docking technology. Methods Pathological targets of radiation ulcers were screened using GeneCards database.… read more here.
Keywords: radiation ulcers; radiation; core targets; dasatinib ... See more keywords