Design of HIV Coreceptor Derived Peptides That Inhibit Viral Entry at Submicromolar Concentrations.
Sign Up to like & getrecommendations! Published in 2017 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.7b00155
Abstract: HIV/AIDS continues to pose an enormous burden on global health. Current HIV therapeutics include inhibitors that target the enzymes HIV protease, reverse transcriptase, and integrase, along with viral entry inhibitors that block the initial steps… read more here.
Keywords: hiv coreceptor; hiv; coreceptor; peptides inhibit ... See more keywords
Performance comparison of next-generation sequencing platforms for determining HIV-1 coreceptor use
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep42215
Abstract: The coreceptor used by HIV-1 must be determined before a CCR5 antagonist, part of the arsenal of antiretroviral drugs, is prescribed because viruses that enter cells using the CXCR4 coreceptor are responsible for treatment failure.… read more here.
Keywords: hiv; coreceptor; next generation; generation sequencing ... See more keywords
High-Sequence Diversity and Rapid Virus Turnover Contribute to Higher Rates of Coreceptor Switching in Treatment-Experienced Subjects with HIV-1 Viremia.
Sign Up to like & getrecommendations! Published in 2017 at "AIDS research and human retroviruses"
DOI: 10.1089/aid.2016.0153
Abstract: Coreceptor switching from CCR5 to CXCR4 is common during chronic HIV-1 infection, but is even more common in individuals who have failed antiretroviral therapy (ART). Prior studies have suggested rapid mutation and/or recombination of HIV-1… read more here.
Keywords: diversity; coreceptor; efficiency via; coreceptor switching ... See more keywords
Effect of Amino Acid Substitutions Within the V3 Region of HIV-1 CRF01_AE on Interaction with CCR5-Coreceptor.
Sign Up to like & getrecommendations! Published in 2017 at "AIDS research and human retroviruses"
DOI: 10.1089/aid.2017.0044
Abstract: Specific amino acids within the V3 loop of HIV-1 CRF01_AE envelope glycoprotein that are involved in the interaction with CCR5/CXCR4 coreceptors, are not well characterized. We generated V3 mutants using polymerase chain reaction (PCR)-based site-directed… read more here.
Keywords: interaction ccr5; coreceptor; hiv crf01;
C-C Chemokine receptor-like 2 (CCRL2) acts as coreceptor for human immunodeficiency virus-2.
Sign Up to like & getrecommendations! Published in 2020 at "Briefings in bioinformatics"
DOI: 10.1093/bib/bbaa333
Abstract: INTRODUCTION Most of the typical chemokine receptors (CKRs) have been identified as coreceptors for a variety of human and simian immunodeficiency viruses (HIVs and SIVs). This study evaluated CCRL2 to examine if it was an… read more here.
Keywords: immunodeficiency; ccrl2; hiv siv; hiv ... See more keywords
Pace of Coreceptor Tropism Switch in HIV-1-Infected Individuals after Recent Infection
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Virology"
DOI: 10.1128/jvi.00793-17
Abstract: ABSTRACT HIV-1 entry into target cells influences several aspects of HIV-1 pathogenesis, including viral tropism, HIV-1 transmission and disease progression, and response to entry inhibitors. The evolution from CCR5- to CXCR4-using strains in a given… read more here.
Keywords: tropism switch; coreceptor; hiv infected; cxcr4 using ... See more keywords
A Coreceptor-Mimetic Peptide Enhances the Potency of V3-Glycan Antibodies
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Virology"
DOI: 10.1128/jvi.01653-18
Abstract: HIV-1 requires both the cellular receptor CD4 and a tyrosine-sulfated coreceptor to infect its target cells. CD4-Ig is a fusion of the HIV-1-binding domains of CD4 with an antibody Fc domain. Previous studies have demonstrated… read more here.
Keywords: coreceptor mimetic; potency; coreceptor; sulfopeptide ... See more keywords
Abstract A80: Functionally significant heterogeneity in apparently homogenous naive CD8 T cell populations
Sign Up to like & getrecommendations! Published in 2017 at "Cancer immunology research"
DOI: 10.1158/2326-6074.tumimm16-a80
Abstract: Functional heterogeneity in apparently homogenous T cell populations has been well reported. However, what factors lead to such variations within a T cell population is still unclear. Depending upon the time of egress from the… read more here.
Keywords: cd8 cell; cd8; heterogeneity; coreceptor ... See more keywords
Inhibition of Endothelial SCUBE2 (Signal Peptide-CUB-EGF Domain-Containing Protein 2), a Novel VEGFR2 (Vascular Endothelial Growth Factor Receptor 2) Coreceptor, Suppresses Tumor Angiogenesis
Sign Up to like & getrecommendations! Published in 2018 at "Arteriosclerosis, Thrombosis, and Vascular Biology"
DOI: 10.1161/atvbaha.117.310506
Abstract: Objective— SCUBE2 (signal peptide-CUB-EGF domain-containing protein 2), expressed on the endothelial cell surface, functions as a novel coreceptor for VEGFR2 (vascular endothelial growth factor receptor 2) and enhances VEGF-induced signaling in adult angiogenesis. However, whether… read more here.
Keywords: angiogenesis; coreceptor; growth; vegfr2 ... See more keywords
CCR5 as a Coreceptor for Human Immunodeficiency Virus and Simian Immunodeficiency Viruses: A Prototypic Love-Hate Affair
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.835994
Abstract: CCR5, a chemokine receptor central for orchestrating lymphocyte/cell migration to the sites of inflammation and to the immunosurveillance, is involved in the pathogenesis of a wide spectrum of health conditions, including inflammatory diseases, viral infections,… read more here.
Keywords: cd4; infection; virus; ccr5 ... See more keywords
Conservation and Enhanced Binding of SARS-CoV-2 Omicron Spike Protein to Coreceptor Neuropilin-1 Predicted by Docking Analysis
Sign Up to like & getrecommendations! Published in 2022 at "Infectious Disease Reports"
DOI: 10.3390/idr14020029
Abstract: The Omicron variant of SARS-CoV-2 bears peptide sequence alterations that correlate with a higher infectivity than was observed in the original SARS-CoV-2 isolated from Wuhan, China. We analyzed the CendR motif of spike protein and… read more here.
Keywords: analysis; conservation enhanced; sars cov; spike protein ... See more keywords