A functional LSD1 coregulator screen reveals a novel transcriptional regulatory cascade connecting R-loop homeostasis with epigenetic regulation
Sign Up to like & getrecommendations! Published in 2021 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkab180
Abstract: Abstract The lysine specific demethylase 1 (LSD1) plays a pivotal role in cellular differentiation by regulating the expression of key developmental genes in concert with different coregulatory proteins. This process is impaired in different cancer… read more here.
Keywords: novel transcriptional; ddx19a; regulatory cascade; coregulator ... See more keywords
Abstract P1-09-06: Blocking ER coregulator signaling enhances CDK4/6 inhibitor palbociclib therapy in ER-positive advanced breast cancer
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DOI: 10.1158/1538-7445.sabcs17-p1-09-06
Abstract: BACKGROUND: Recently,CDK4/6 inhibitors in combination with endocrine therapy (AE/AI/SERDs) is approved for the treatment of ER+ advanced breastcancer (BCa). However, not all patients benefit from CDK4/6 inhibitors therapy. Emerging studies indicate many therapy-resistant tumors retainER… read more here.
Keywords: palbociclib; cancer; coregulator; therapy ... See more keywords
Profiling of 3696 Nuclear Receptor-Coregulator Interactions: A Resource for Biological and Clinical Discovery.
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DOI: 10.1210/en.2018-00149
Abstract: Nuclear receptors (NRs) are ligand-inducible transcription factors that play critical roles in metazoan development, reproduction, and physiology and therefore are implicated in a broad range of pathologies. The transcriptional activity of NRs critically depends on… read more here.
Keywords: profiling 3696; coregulator interactions; coregulator; clinical discovery ... See more keywords
Estrogen receptor coregulator binding modulators (ERXs) effectively target estrogen receptor positive human breast cancers
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DOI: 10.7554/elife.26857
Abstract: The majority of human breast cancer is estrogen receptor alpha (ER) positive. While anti-estrogens/aromatase inhibitors are initially effective, resistance to these drugs commonly develops. Therapy-resistant tumors often retain ER signaling, via interaction with critical oncogenic… read more here.
Keywords: receptor; human breast; estrogen receptor; coregulator ... See more keywords