Hydroxamic Acid-Modified Peptide Library Provides Insights into the Molecular Basis for the Substrate Selectivity of HDAC Corepressor Complexes
Sign Up to like & getrecommendations! Published in 2022 at "ACS Chemical Biology"
DOI: 10.1021/acschembio.2c00510
Abstract: Targeting the lysine deacetylase activity of class I histone deacetylases (HDACs) is potentially beneficial for the treatment of several diseases including human immunodeficiency virus (HIV) infection, Alzheimer’s disease, and various cancers. It is therefore important… read more here.
Keywords: hdac corepressor; corepressor complexes; acid; substrate ... See more keywords
Nuclear KRT19 is a transcriptional corepressor promoting histone deacetylation and liver tumorigenesis
Sign Up to like & getrecommendations! Published in 2024 at "Hepatology"
DOI: 10.1097/hep.0000000000000875
Abstract: Background and Aims: Epigenetic reprogramming and escape from terminal differentiation are poorly understood enabling characteristics of liver cancer. Keratin 19 (KRT19), classically known to form the intermediate filament cytoskeleton, is a marker of stemness and… read more here.
Keywords: cancer; liver tumorigenesis; krt19; corepressor ... See more keywords
The Role of CtBP1 in Oncogenic Processes and Its Potential as a Therapeutic Target
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1535-7163.mct-16-0592
Abstract: Transcriptional corepressor proteins have emerged as an important facet of cancer etiology. These corepressor proteins are often altered by loss- or gain-of-function mutations, leading to transcriptional imbalance. Thus, research directed at expanding our current understanding… read more here.
Keywords: corepressor; role; cancer; role ctbp1 ... See more keywords
Abstract 3023: Master corepressor inactivation through oncogene suppressor RAI2 mediated polymerization
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Research"
DOI: 10.1158/1538-7445.am2024-3023
Abstract: Imbalanced transcription of a large number of genes can be caused at various levels, ranging from alterations in individual transcription factors to dysfunctional corepressor and coactivator complexes [1]. C-terminal binding proteins (CtBPs) are ubiquitous master… read more here.
Keywords: cancer; rai2; corepressor; polymerization ... See more keywords
OPTHiS Identifies the Molecular Basis of the Direct Interaction between CSL and SMRT Corepressor
Sign Up to like & getrecommendations! Published in 2018 at "Molecules and Cells"
DOI: 10.14348/molcells.2018.0196
Abstract: Notch signaling is an evolutionarily conserved pathway and involves in the regulation of various cellular and developmental processes. Ligand binding releases the intracellular domain of Notch receptor (NICD), which interacts with DNA-bound CSL [CBF1/Su(H)/Lag-1] to… read more here.
Keywords: csl; csl smrt; molecular basis; corepressor ... See more keywords
More than a Corepressor: The Role of CoREST Proteins in Neurodevelopment
Sign Up to like & getrecommendations! Published in 2020 at "eNeuro"
DOI: 10.1523/eneuro.0337-19.2020
Abstract: Abstract The molecular mechanisms governing normal neurodevelopment are tightly regulated by the action of transcription factors. Repressor element 1 (RE1) silencing transcription factor (REST) is widely documented as a regulator of neurogenesis that acts by… read more here.
Keywords: corepressor role; role; corepressor; corest proteins ... See more keywords
The role of corepressor HOS15-mediated epigenetic regulation of flowering
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Plant Science"
DOI: 10.3389/fpls.2022.1101912
Abstract: Regulation of gene expression underpins gene function and is essential for regulation of physiological roles. Epigenetic modifications regulate gene transcription by physically facilitating relaxation or condensation of target loci in chromatin. Transcriptional corepressors are involved… read more here.
Keywords: hos15; gene expression; regulation; gene ... See more keywords
Competitive Ligand-Induced Recruitment of Coactivators to Specific PPARα/δ/γ Ligand-Binding Domains Revealed by Dual-Emission FRET and X-Ray Diffraction of Cocrystals
Sign Up to like & getrecommendations! Published in 2025 at "Antioxidants"
DOI: 10.3390/antiox14040494
Abstract: Peroxisome proliferator-activated receptors (PPARs), composed of the α/δ/γ subtypes, are ligand-activated nuclear receptors/transcription factors that sense endogenous fatty acids or therapeutic drugs to regulate lipid/glucose metabolism and oxidative stress. PPAR forms a multiprotein complex with… read more here.
Keywords: ppar; coactivator; ligand; corepressor ... See more keywords