Corilagin induces apoptosis and inhibits HMBG1/PI3K/AKT signaling pathways in a rat model of gastric carcinogenesis induced by methylnitronitrosoguanidine
Sign Up to like & getrecommendations! Published in 2022 at "Environmental Toxicology"
DOI: 10.1002/tox.23478
Abstract: Gastric cancer, invasive cancer of the gastrointestinal tract, found in developing countries. Chemotherapy to patients with advanced gastric cancer, exhibits greater drug resistance to standard chemotherapy drugs. Therefore, important to establish anti‐cancer drugs that are… read more here.
Keywords: corilagin; apoptosis inhibits; gastric cancer; induces apoptosis ... See more keywords
Corilagin induces laryngeal cancer antiproliferation and inhibits growth factor and cytokine signaling pathways in vitro and in vivo
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Functional Foods"
DOI: 10.1016/j.jff.2020.103947
Abstract: Abstract Laryngeal cancer is a prevalent malignancy of the head and neck with a high rate of mortality. Corilagin, a natural gallic acid derivative, was isolated from PhmLlanthi Fructus, a “drug homologous food”, and its… read more here.
Keywords: signaling pathways; vitro vivo; inhibits growth; laryngeal cancer ... See more keywords
Metabolic profiling analysis of corilagin in vivo and in vitro using high‐performance liquid chromatography quadrupole time‐of‐flight mass spectrometry
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Pharmaceutical and Biomedical Analysis"
DOI: 10.1016/j.jpba.2018.12.013
Abstract: HighlightsThe metabolic profile of corilagin in vivo and in vitro were investigated for the first time.Twenty‐four metabolites of corilagin in rat biological samples (urine, feces, plasma and tissues) were firstly reported.The phase II conjugate metabolites… read more here.
Keywords: vivo vitro; analysis; time; corilagin ... See more keywords
The Protective Potential of Phyllanthus niruri and Corilagin on Gastric Lesions Induced in Rodents by Different Harmful Agents.
Sign Up to like & getrecommendations! Published in 2017 at "Planta medica"
DOI: 10.1055/s-0042-107356
Abstract: The gastroprotective effect of the methanol extract of Phyllantus niruri and its main constituent, corilagin, were studied in vivo. The extract (50, 125, or 250 mg/kg, p. o.) inhibited ethanol-induced lesions in rats by 43 % (p read more here.
Keywords: protective potential; potential phyllanthus; niruri; corilagin ... See more keywords
Antioxidant and pro-angiogenic effects of corilagin in rat cerebral ischemia via Nrf2 activation
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.22023
Abstract: The nuclear factor erythroid-2-related factor 2 (Nrf2) pathway has been considered as a potential target for neuroprotection in stroke. The aim of present study was to determine whether corilagin, a novel Nrf2 activator, can protect… read more here.
Keywords: pro angiogenic; antioxidant pro; ischemia; activation ... See more keywords
Corilagin Ameliorates Con A-Induced Hepatic Injury by Restricting M1 Macrophage Polarization
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.807509
Abstract: Immune-mediated hepatic injury plays a key role in the initiation and pathogenesis of diverse liver diseases. However, treatment choice for immune-mediated hepatic injury remains limited. Corilagin, a natural ellagitannin extracted from various traditional Chinese medicines,… read more here.
Keywords: mediated hepatic; corilagin; hepatic injury; immune mediated ... See more keywords
Role of NADPH Oxidase-Derived ROS-Mediated IL-6/STAT3 and MAPK/NF-κB Signaling Pathways in Protective Effect of Corilagin against Acetaminophen-Induced Liver Injury in Mice
Sign Up to like & getrecommendations! Published in 2023 at "Biology"
DOI: 10.3390/biology12020334
Abstract: Simple Summary Acetaminophen overdose causes acute liver injury by excessive oxidative stress. The present study examines the mechanisms underlying the protective effect of corilagin against acetaminophen-induced liver injury. Our results showed that corilagin attenuates the… read more here.
Keywords: corilagin; liver injury; protective effect; induced liver ... See more keywords
The Effect and Mechanism of Corilagin from Euryale Ferox Salisb Shell on LPS-Induced Inflammation in Raw264.7 Cells
Sign Up to like & getrecommendations! Published in 2023 at "Foods"
DOI: 10.3390/foods12050979
Abstract: (1) Background: Euryale ferox Salisb is a large aquatic plant of the water lily family and an edible economic crop with medicinal value. The annual output of Euryale ferox Salisb shell in China is higher… read more here.
Keywords: euryale ferox; salisb shell; effect; corilagin ... See more keywords