The serine protease CORIN promotes progression of gastric cancer by mediating the ERK1/2 MAPK pathway
Sign Up to like & getrecommendations! Published in 2024 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.23739
Abstract: The serine protease CORIN catalyzes pro‐atrial natriuretic peptide (pro‐ANP) into an active ANP and maintains homeostasis of the internal environment. However, it is unclear whether CORIN participates in the regulation of tumor progression. We analyzed… read more here.
Keywords: erk1 mapk; progression; corin; serine protease ... See more keywords
Corin is a key regulator of endochondral ossification and bone development via modulation of vascular endothelial growth factor A expression
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Tissue Engineering and Regenerative Medicine"
DOI: 10.1002/term.2760
Abstract: Corin has been studied extensively within the vascular system and is known to regulate blood pressure. We have shown that corin is one of the most highly upregulated genes during osteogenic differentiation of human adipose‐derived… read more here.
Keywords: medicine; corin; bone; expression ... See more keywords
Corin is highly expressed in atherosclerosis models.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.08.173
Abstract: Corin is a serine protease mainly expressed in the heart, where it regulates blood pressure and cardiac function through activating pro-atrial natriuretic peptide (pro-ANP) to ANP. Its expression has also been detected in non-cardiac tissues.… read more here.
Keywords: corin highly; corin; highly expressed; expression ... See more keywords
Association of rs2271037 and rs3749585 polymorphisms in CORIN with susceptibility to hypertension in a Chinese Han population: A case-control study.
Sign Up to like & getrecommendations! Published in 2018 at "Gene"
DOI: 10.1016/j.gene.2018.01.080
Abstract: Corins are membrane-bound protease that regulates blood pressure by activating the natriuretic peptides. These pro-atrial natriuretic peptide convertases are essential for sodium homeostasis and normal blood pressure. CORIN variants have been identified in humans and… read more here.
Keywords: rs3749585; susceptibility; study; corin ... See more keywords
Aberrant corin and PCSK6 in placentas of the maternal hyperinsulinemia IUGR rat model.
Sign Up to like & getrecommendations! Published in 2020 at "Pregnancy hypertension"
DOI: 10.1016/j.preghy.2020.05.007
Abstract: OBJECTIVES Corin is a protease that converts pro-atrial natriuretic peptide (pro-ANP) to ANP. While the involvement of ANP in the cardiovascular regulation is well established, there is increasing evidence that the pregnant uterus produces ANP,… read more here.
Keywords: aberrant corin; pcsk6 placentas; corin; placentas maternal ... See more keywords
Function and regulation of corin in physiology and disease.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical Society transactions"
DOI: 10.1042/bst20190760
Abstract: Atrial natriuretic peptide (ANP) is of major importance in the maintenance of electrolyte balance and normal blood pressure. Reduced plasma ANP levels are associated with the increased risk of cardiovascular disease. Corin is a type… read more here.
Keywords: physiology; function regulation; physiology disease; corin ... See more keywords
Siberian cats help in solving part of the mystery surrounding golden cats.
Sign Up to like & getrecommendations! Published in 2021 at "Animal genetics"
DOI: 10.1111/age.13076
Abstract: Golden cats have been appreciated since the beginning of the cat fancy. Golden is a modification of the tabby coat. In the Siberian breed, a specific golden phenotype, named sunshine, has been described. Sunshine tabby… read more here.
Keywords: siberian cats; corin; corin 2383c; tabby ... See more keywords
Golden cats: A never‐ending story!
Sign Up to like & getrecommendations! Published in 2022 at "Animal Genetics"
DOI: 10.1111/age.13228
Abstract: Abstract In the British feline breed a golden coat modification, called light‐gold, akita or copper, was reported by breeders during the 2010s. This modification restricted eumelanin to the tip of the tail and hairs showed… read more here.
Keywords: never ending; golden cats; cats never; corin ... See more keywords
Association between CORIN methylation and hypertension in Chinese adults.
Sign Up to like & getrecommendations! Published in 2022 at "Postgraduate medical journal"
DOI: 10.1136/pmj-2022-141802
Abstract: BACKGROUND Corin, a physical activator of atrial natriuretic peptide, has been associated with hypertension with unclear mechanisms. Here, we aimed to examine whether CORIN gene methylation was involved in the underlying molecular mechanisms. METHODS DNA… read more here.
Keywords: methylation; hypertension; association corin; corin ... See more keywords
Abstract 4359493: PRECISION TARGETING OF CORIN AND FURIN: A TRANSLATIONAL LEAP IN HEART FAILURE AND HYPERTENSION THERAPY
Sign Up to like & getrecommendations! Published in 2025 at "Circulation"
DOI: 10.1161/circ.152.suppl_3.4359493
Abstract: Background: Heart failure and hypertension remain leading causes of morbidity and mortality worldwide. Proteolytic regulation of natriuretic peptides (NPs) by corin and furin is essential for cardiovascular homeostasis. Dysregulation of these proteases, due to genetic… read more here.
Keywords: hypertension; corin; corin furin; heart failure ... See more keywords
Associations between potentially functional CORIN SNPs and serum corin levels in the Chinese Han population
Sign Up to like & getrecommendations! Published in 2019 at "BMC Genetics"
DOI: 10.1186/s12863-019-0802-4
Abstract: BackgroundCorin is an important convertase involved in the natriuretic peptide system and may indirectly regulate blood pressure. Genetic factors relate to corin remain unclear. The purpose of the current study was to comprehensively examine the… read more here.
Keywords: potentially functional; corin levels; corin; serum corin ... See more keywords