Development and Evaluation of a Diclofenac‐Loaded Thermogel for Topical Treatment of Corneal Alkali Burns
Sign Up to like & getrecommendations! Published in 2024 at "Macromolecular Materials and Engineering"
DOI: 10.1002/mame.202400164
Abstract: Corneal alkali burns have become a frequent and urgent issue in ophthalmology, but current treatments are limited. To address this, a diclofenac‐loaded thermogel with anti‐inflammatory agents is developed to target inflammation and improve drug delivery… read more here.
Keywords: loaded thermogel; alkali burns; corneal alkali; diclofenac loaded ... See more keywords
Irradiated umbilical cord mesenchymal stem cell-coated high oxygen-permeable hydrogel lenses inhibit corneal inflammation and neovascularization after corneal alkali burns
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-025-95007-9
Abstract: Corneal alkali burns can cause persistent inflammation and corneal neovascularization. In this study, we divided corneal alkali burned rabbits into the untreated group, the blank lens group, the radiation-treated umbilical cord mesenchymal stem cells (UCMSC)… read more here.
Keywords: neovascularization; corneal; corneal alkali; inflammation ... See more keywords
Subconjunctival administration of mesenchymal stem cells alleviates ocular inflammation in a murine model of corneal alkali burn.
Sign Up to like & getrecommendations! Published in 2023 at "Stem cells"
DOI: 10.1093/stmcls/sxad027
Abstract: Corneal alkali burns cause extensive damage not only on the cornea but also into the intraocular tissues. As an anti-inflammatory therapy, subconjunctival administration of mesenchymal stem cells (MSCs) for corneal protection after corneal alkali burn… read more here.
Keywords: burn; subconjunctival administration; corneal alkali; mscs ... See more keywords
The Wound Healing Effect of Doxycycline after Corneal Alkali Burn in Rats
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DOI: 10.1155/2019/5168652
Abstract: Purpose To evaluate the wound healing effect of doxycycline and its underlying mechanisms in a rat model of corneal alkali burn. Methods Male SD rats were administered 1.0 N NaOH in the right cornea for 25… read more here.
Keywords: wound healing; corneal alkali; group; alkali burn ... See more keywords
The Therapeutic Effects and Possible Mechanism of Pranoprofen in Mouse Model of Corneal Alkali Burns
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Ophthalmology"
DOI: 10.1155/2020/7485912
Abstract: Objective To investigate therapeutic effects and possible mechanism of pranoprofen in a mouse model of corneal alkali burns and provide new evidence for the clinical treatment of corneal alkali burns. Methods A unilateral alkali burn… read more here.
Keywords: saline group; corneal; alkali burns; corneal alkali ... See more keywords
Evaluation of Clinical and Histological Outcomes of Adipose-Derived Mesenchymal Stem Cells in a Rabbit Corneal Alkali Burn Model
Sign Up to like & getrecommendations! Published in 2021 at "Stem Cells International"
DOI: 10.1155/2021/6610023
Abstract: To assess effects of adipose-derived mesenchymal stem cells (AMSCs) in corneal alkali injuries in an experimental animal model. Twenty white New Zealand rabbits were included in the study. The animal models were randomly divided into… read more here.
Keywords: derived mesenchymal; corneal alkali; group; stem cells ... See more keywords
Transforming corneal alkali burn treatment: unveiling mechanisms and pioneering therapies from bench to bedside
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Translational Medicine"
DOI: 10.1186/s12967-025-07102-0
Abstract: Corneal alkali burns are severe ocular injuries characterized by extensive tissue damage, inflammation, oxidative stress, and neovascularization, which often lead to long-term visual impairment and corneal fibrosis. This review comprehensively examines the mechanisms underlying alkali… read more here.
Keywords: treatment; transforming corneal; corneal alkali; alkali burn ... See more keywords
Topical Pirfenidone-Loaded Liposomes Ophthalmic Formulation Reduces Haze Development after Corneal Alkali Burn in Mice
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics14020316
Abstract: Corneal chemical burns (CCBs) frequently result in corneal fibrosis or haze, an opacity of the cornea that obstructs vision and induces corneal blindness. Diverse strategies have been employed to prevent or reduce CCB-related corneal haze.… read more here.
Keywords: formulation; corneal alkali; topical pirfenidone; corneal ... See more keywords