Blockade of costimulatory CD27/CD70 pathway promotes corneal allograft survival.
Sign Up to like & getrecommendations! Published in 2020 at "Experimental eye research"
DOI: 10.1016/j.exer.2020.108190
Abstract: PURPOSE To determine whether the CD27/CD70 pathway plays a significant role in corneal allograft rejection by investigating the effect of blocking the CD27/CD70 pathway by anti-CD70 antibody on corneal allograft survival. METHODS Orthotopic penetrating keratoplasty… read more here.
Keywords: corneal allograft; cd70; cd27 cd70; cd70 pathway ... See more keywords
MicroRNA-122 ameliorates corneal allograft rejection through the downregulation of its target CPEB1
Sign Up to like & getrecommendations! Published in 2017 at "Cell Death Discovery"
DOI: 10.1038/cddiscovery.2017.46
Abstract: This corrects the article DOI: 10.1038/cddiscovery.2017.21 read more here.
Keywords: corneal allograft; rejection downregulation; microrna 122; allograft rejection ... See more keywords
Enhanced autophagy alleviated corneal allograft rejection via inhibiting NLRP3 inflammasome activity
Sign Up to like & getrecommendations! Published in 2022 at "American Journal of Transplantation"
DOI: 10.1111/ajt.16968
Abstract: Autophagy has been reported to be involved in many aspects of innate and adaptive immunity. Manipulating autophagy is recognized as a promising therapeutic approach for treating immunological diseases, including allograft rejection, and graft‐versus‐host disease. However,… read more here.
Keywords: corneal allograft; rejection; nlrp3 inflammasome; allograft rejection ... See more keywords
Effector and Regulatory T Cell Trafficking in Corneal Allograft Rejection
Sign Up to like & getrecommendations! Published in 2017 at "Mediators of Inflammation"
DOI: 10.1155/2017/8670280
Abstract: Corneal transplantation is among the most prevalent and successful forms of solid tissue transplantation in humans. Failure of corneal allograft is mainly due to immune-mediated destruction of the graft, a complex and highly coordinated process… read more here.
Keywords: corneal allograft; allograft rejection; effector regulatory; graft ... See more keywords
The effects of local administration of mesenchymal stem cells on rat corneal allograft rejection
Sign Up to like & getrecommendations! Published in 2018 at "BMC Ophthalmology"
DOI: 10.1186/s12886-018-0802-6
Abstract: BackgroundMesenchymal stem cells (MSCs) have been reported to promote long-term cellular and organ transplant acceptance due to their immunotherapeutic characteristics. Previous work from our lab using a rat allograft model has shown that systemic infusion… read more here.
Keywords: corneal allograft; effects local; allograft rejection; allograft ... See more keywords
High-throughput RNA-sequencing identifies mesenchymal stem cell-induced immunological signature in a rat model of corneal allograft rejection
Sign Up to like & getrecommendations! Published in 2019 at "PLoS ONE"
DOI: 10.1371/journal.pone.0222515
Abstract: Objective The immune rejection mediated by CD4+ T cell and antigen presenting macrophages is the leading cause of corneal transplantation failure. Bone marrow-derived mesenchymal stem cells (BM-MSCs) possess robust immunomodulatory potentials, and have been shown… read more here.
Keywords: allograft rejection; corneal allograft; corneal; cell ... See more keywords