Allogeneic Ex Vivo Expanded Corneal Epithelial Stem Cell Transplantation: A Randomized Controlled Clinical Trial
Sign Up to like & getrecommendations! Published in 2019 at "Stem Cells Translational Medicine"
DOI: 10.1002/sctm.18-0140
Abstract: Limbal stem cell deficiency (LSCD) is a disease resulting from the loss or dysfunction of epithelial stem cells, which seriously impairs sight. Autologous limbal stem cell transplantation is effective in unilateral or partial bilateral disease… read more here.
Keywords: medicine; trial; epithelial stem; corneal epithelial ... See more keywords
Silencing TLR4/MyD88/NF-κB Signaling Pathway Alleviated Inflammation of Corneal Epithelial Cells Infected by ISE
Sign Up to like & getrecommendations! Published in 2020 at "Inflammation"
DOI: 10.1007/s10753-020-01363-1
Abstract: The regulatory role of toll-like receptor 4 (TLR4) in the inactivate staphylococcus epidermidis (ISE)-induced cornea inflammation is not well investigated. Here, TLR4 silence could decrease inflammatory cytokines in corneal epithelial cells treated with ISE. The… read more here.
Keywords: epithelial cells; ise; corneal epithelial; inflammation ... See more keywords
Use of commercially available sodium hyaluronate 0.18% eye drops for corneal epithelial healing in diabetic patients
Sign Up to like & getrecommendations! Published in 2018 at "International Ophthalmology"
DOI: 10.1007/s10792-018-1057-1
Abstract: PurposeTo evaluate the effect of topical sodium hyaluronate (SH) 0.18% treatment on corneal epithelial healing after epithelial debridement in pars plana vitrectomy in diabetic patients.MethodThis is prospective and randomized clinical trial. Our study population included… read more here.
Keywords: corneal; epithelial healing; corneal epithelial; group ... See more keywords
Cisd2 plays an essential role in corneal epithelial regeneration
Sign Up to like & getrecommendations! Published in 2021 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2021.103654
Abstract: Background Age-related changes affecting the ocular surface cause vision loss in the elderly. Cisd2 deficiency drives premature aging in mice as well as resulting in various ocular surface abnormalities. Here we investigate the role of… read more here.
Keywords: ocular surface; cisd2 deficiency; cisd2; corneal epithelial ... See more keywords
Water extract of indoor dust induces tight junction disruption in normal human corneal epithelial cells.
Sign Up to like & getrecommendations! Published in 2018 at "Environmental pollution"
DOI: 10.1016/j.envpol.2018.08.085
Abstract: In corneal epithelium, tight junctions play a vital role in its barrier function. Human cornea is highly susceptible to damage by dust. Continued daily exposure to dust has been associated with increased risks of corneal… read more here.
Keywords: water extract; water; corneal epithelial; barrier function ... See more keywords
Recovery of the sub‐basal nerve plexus and superficial nerve terminals after corneal epithelial injury in mice
Sign Up to like & getrecommendations! Published in 2018 at "Experimental Eye Research"
DOI: 10.1016/j.exer.2018.03.012
Abstract: Abstract Our aim was to compare regeneration of the sub‐basal nerve plexus (SBNP) and superficial nerve terminals (SNT) following corneal epithelial injury. We also sought to compare agreement when quantifying nerve parameters using different image… read more here.
Keywords: nerve plexus; corneal epithelial; injury; nerve ... See more keywords
Sirt3 regulates mitophagy level to promote diabetic corneal epithelial wound healing
Sign Up to like & getrecommendations! Published in 2019 at "Experimental Eye Research"
DOI: 10.1016/j.exer.2019.02.011
Abstract: ABSTRACT We aim to investigate how Sirt3 (silent mating type information regulation 2 homolog 3) promoting diabetic corneal epithelial wound healing by regulating mitophagy. The effect of HG(High Glucose, 25mM D‐glucose) on Sirt3 and LC3B(light… read more here.
Keywords: wound healing; corneal; corneal epithelial; diabetic corneal ... See more keywords
Vitamin D receptor and metabolite effects on corneal epithelial cell gap junction proteins.
Sign Up to like & getrecommendations! Published in 2019 at "Experimental eye research"
DOI: 10.1016/j.exer.2019.107776
Abstract: Vitamin D is a fat-soluble prohormone that can be activated both systemically and within individual tissues. Our lab has previously demonstrated that the corneal epithelium can activate vitamin D and that the vitamin D metabolites… read more here.
Keywords: gap; gap junction; corneal epithelial; 24r 2d3 ... See more keywords
PLGA nanoparticles containing Lingzhi extracts rescue corneal epithelial cells from oxidative damage.
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DOI: 10.1016/j.exer.2021.108539
Abstract: Oxidative stress-related ocular surface epithelial damage can be initiated by ambient oxygen, UV radiation, and chemical burns. The oxidative damage to cornea can lead to inflammation and even vision loss. Lingzhi (Ganoderma lucidum) is a… read more here.
Keywords: epithelial cells; lzh nps; oxidative damage; corneal epithelial ... See more keywords
Hyperglycemia-reduced NAD+ biosynthesis impairs corneal epithelial wound healing in diabetic mice.
Sign Up to like & getrecommendations! Published in 2020 at "Metabolism: clinical and experimental"
DOI: 10.1016/j.metabol.2020.154402
Abstract: OBJECTIVE Nicotinamide adenine dinucleotide (NAD) is an essential molecule participating in multiple physiological and pathophysiological processes. In diabetic cornea, the NAD+-consuming enzyme SIRT1 was down-regulated and contributed to the delayed wound healing. However, the impact… read more here.
Keywords: wound healing; epithelial wound; corneal epithelial; nad biosynthesis ... See more keywords
A proof‐of‐concept clinical trial using mesenchymal stem cells for the treatment of corneal epithelial stem cell deficiency
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DOI: 10.1016/j.trsl.2018.11.003
Abstract: &NA; Ocular stem cell transplantation derived from either autologous or allogeneic donor corneoscleral junction is a functional cell therapy to manage extensive and/or severe limbal stem cell deficiencies that lead to corneal epithelial failure. Mesenchymal… read more here.
Keywords: trial; corneal epithelial; stem cell; proof concept ... See more keywords