Resolution of Corneal Fibrosis After Descemet’s Stripping Automated Endothelial Keratoplasty: A Case Report
Sign Up to like & getrecommendations! Published in 2020 at "Ophthalmology and Therapy"
DOI: 10.1007/s40123-020-00244-y
Abstract: Purpose To report the resolution of anterior corneal fibrosis after Descemet’s stripping automated endothelial keratoplasty (DSAEK), in a patient with chronic corneal edema and anterior stromal scarring. Methods A 63-year-old woman, with a history of… read more here.
Keywords: corneal; fibrosis; fibrosis descemet; stripping automated ... See more keywords
The Long Noncoding RNA LINC00963 Inhibits Corneal Fibrosis Scar Formation by Targeting miR-143-3p
Sign Up to like & getrecommendations! Published in 2022 at "DNA and Cell Biology"
DOI: 10.1089/dna.2021.1034
Abstract: Corneal fibrosis is a complication of severe corneal injury, one of the major causes of vision loss. The formation of myofibroblasts has emerged as a key stimulative factor of corneal fibrosis. In the current study,… read more here.
Keywords: linc00963; mir 143; formation; fibrosis ... See more keywords
Glucosamine impedes transforming growth factor β1-mediated corneal fibroblast differentiation by targeting Krüppel-like factor 4
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Biomedical Science"
DOI: 10.1186/s12929-019-0566-1
Abstract: BackgroundTransforming growth factor (TGF) family members play important roles in the regulation of corneal integrity, and the pathogenesis of corneal fibrosis. Currently, there are no effective agents targeting TGF-β signaling to diminish corneal fibrosis. Glucosamine… read more here.
Keywords: corneal fibrosis; factor; differentiation; glcn ... See more keywords
Evaluation of a novel combination of TRAM-34 and ascorbic acid for the treatment of corneal fibrosis in vivo
Sign Up to like & getrecommendations! Published in 2022 at "PLoS ONE"
DOI: 10.1371/journal.pone.0262046
Abstract: Corneal injury and aberrant wound healing commonly result in corneal fibrosis and subsequent vision loss. Intermediate-conductance calmodulin/calcium-activated K+ channels (KCa3.1) have been shown to promote fibrosis in non-ocular and ocular tissues via upregulation of transforming… read more here.
Keywords: ascorbic acid; tram; treatment; fibrosis ... See more keywords
Therapeutic potential of topical administration of acriflavine against hypoxia-inducible factors for corneal fibrosis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.996635
Abstract: Transdifferentiation of keratocytes into fibroblasts or further into myofibroblasts, which produced denser and more disorganized extracellular matrix, is the major cause of corneal fibrosis and scarring, leading to corneal blindness. TGF-β1 is the critical cytokine… read more here.
Keywords: hypoxia inducible; administration acriflavine; fibrosis; corneal fibrosis ... See more keywords
Extracellular Vesicles in Corneal Fibrosis/Scarring
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23115921
Abstract: Communication between cells and the microenvironment is a complex, yet crucial, element in the development and progression of varied physiological and pathological processes. Accumulating evidence in different disease models highlights roles of extracellular vesicles (EVs),… read more here.
Keywords: fibrosis scarring; vesicles corneal; extracellular vesicles; corneal fibrosis ... See more keywords