ECM-like adhesive hydrogel for the regeneration of large corneal stromal defects.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202300192
Abstract: The repair of large-diameter corneal stroma defects is a major clinical problem. Although some studies have attempted to use hydrogels to repair corneal damage, most of these hydrogels can only be used for focal stromal… read more here.
Keywords: hydrogel; corneal; stromal defects; like adhesive ... See more keywords
Thymic stromal lymphopoietin is expressed in human corneal stromal cells and secreted upon protease‐activated receptor 1 activation
Sign Up to like & getrecommendations! Published in 2017 at "IUBMB Life"
DOI: 10.1002/iub.1644
Abstract: Thymic stromal lymphopoietin (TSLP) is an interleukin‐7 (IL‐7) like cytokine that triggers inflammatory responses through activating dendritic cell. It is demonstrated to be involved in a number of disorders, including cancer, gastrointestinal diseases, and autoimmune… read more here.
Keywords: corneal; protease; thymic stromal; stromal cells ... See more keywords
Scaffold‐free tissue engineering of functional corneal stromal tissue
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Tissue Engineering and Regenerative Medicine"
DOI: 10.1002/term.2363
Abstract: Blinding corneal scarring is predominately treated with allogeneic graft tissue; however, there is a worldwide shortage of donor tissue leaving millions in need of therapy. Human corneal stromal stem cells (CSSC) have been shown produce… read more here.
Keywords: corneal; scaffold free; corneal stromal; tissue ... See more keywords
The architecture of corneal stromal striae on optical coherence tomography and histology in an animal model and in humans
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-76963-w
Abstract: The purpose of this study was to use a portable optical coherence tomography (OCT) for characterization of corneal stromal striae (CSS) in an ovine animal model and human corneas with histological correlation, in order to… read more here.
Keywords: optical coherence; animal model; corneal stromal; coherence tomography ... See more keywords
A Case of Sterile Corneal Stromal Infiltration with Hypotonic Maculopathy Under Brimonidine Treatment.
Sign Up to like & getrecommendations! Published in 2022 at "Ocular immunology and inflammation"
DOI: 10.1080/09273948.2022.2087687
Abstract: INTRODUCTION Brimonidine is a commonly used drug for glaucoma treatment, which has been linked to ocular autoimmune disorders like uveitis and conjunctivitis. Corneal pathology under brimonidine is generally less common. CASE DESCRIPTION Here, we report… read more here.
Keywords: brimonidine; hypotonic maculopathy; corneal; case ... See more keywords
3D Functional Corneal Stromal Tissue Equivalent Based on Corneal Stromal Stem Cells and Multi-Layered Silk Film Architecture
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0169504
Abstract: The worldwide need for human cornea equivalents continues to grow. Few clinical options are limited to allogenic and synthetic material replacements. We hypothesized that tissue engineered human cornea systems based on mechanically robust, patterned, porous,… read more here.
Keywords: stromal stem; corneal; tissue; corneal stromal ... See more keywords
Corneal Stromal Regeneration: A Review of Human Clinical Studies in Keratoconus Treatment
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Medicine"
DOI: 10.3389/fmed.2021.650724
Abstract: The use of advanced therapies with stem cells to reconstruct the complex tissue of corneal stroma has gained interest in recent years. Besides, collagen-based scaffolds bioengineering has been offered as another alternative over the last… read more here.
Keywords: corneal; microscopy; regeneration; corneal stromal ... See more keywords
Exosomes Released by Corneal Stromal Cells Show Molecular Alterations in Keratoconus Patients and Induce Different Cellular Behavior
Sign Up to like & getrecommendations! Published in 2022 at "Biomedicines"
DOI: 10.3390/biomedicines10102348
Abstract: Exosomes have been related to various disorders, but their study in relation to ocular pathologies has been limited. In this article, we analyze exosomes produced by corneal stromal cells from healthy individuals and from patients… read more here.
Keywords: exosomes produced; produced healthy; pathology; healthy cells ... See more keywords
Unravelling Novel Roles of Salivary Exosomes in the Regulation of Human Corneal Stromal Cell Migration and Wound Healing
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23084330
Abstract: Salivary exosomes have demonstrated vast therapeutic and diagnostic potential in numerous diseases. This study pioneers previously unexplored roles of SE in the context of corneal wound healing by utilizing primary corneal stromal cells from healthy… read more here.
Keywords: wound healing; t2dms; salivary exosomes; corneal ... See more keywords
Generation of Functional Immortalized Human Corneal Stromal Stem Cells
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232113399
Abstract: In addition to their therapeutic potential in regenerative medicine, human corneal stromal stem cells (CSSCs) could serve as a powerful tool for drug discovery and development. Variations from different donors, their isolation method, and their… read more here.
Keywords: human corneal; stromal stem; csscs; stem cells ... See more keywords