Effect of Core-Crosslinking on Protein Corona Formation on Polymeric Micelles.
Sign Up to like & getrecommendations! Published in 2021 at "Macromolecular bioscience"
DOI: 10.1002/mabi.202000414
Abstract: Most nanomaterials acquire a protein corona upon contact with biological fluids. The magnitude of this effect is strongly dependent both on surface and structure of the nanoparticle. To define the contribution of the internal nanoparticle… read more here.
Keywords: core crosslinking; corona formation; protein corona; plasma proteins ... See more keywords
Mechanistic Understanding of Protein Corona Formation around Nanoparticles: Old Puzzles and New Insights.
Sign Up to like & getrecommendations! Published in 2023 at "Small"
DOI: 10.1002/smll.202301663
Abstract: Although a wide variety of nanoparticles (NPs) have been engineered for use as disease markers or drug delivery agents, the number of nanomedicines in clinical use has hitherto remained small. A key obstacle in nanomedicine… read more here.
Keywords: corona formation; mechanistic understanding; understanding protein; protein corona ... See more keywords
Lipid Corona Formation from Nanoparticle Interactions with Bilayers
Sign Up to like & getrecommendations! Published in 2018 at "Chem"
DOI: 10.1016/j.chempr.2018.09.018
Abstract: Summary Although mixing nanoparticles with certain biological molecules can result in coronas that afford some control over how engineered nanomaterials interact with living systems, corona formation mechanisms remain enigmatic. Here, we report results from experiments… read more here.
Keywords: nanoparticle interactions; formation nanoparticle; formation; lipid corona ... See more keywords
Influence of nanoparticle mechanical property on protein corona formation.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of colloid and interface science"
DOI: 10.1016/j.jcis.2021.08.148
Abstract: A protein corona forms around nanoparticles when they are intravenously injected into the bloodstream. The composition of the protein corona dictates the interactions between nanoparticles and the biological systems thus their immune evasion, blood circulation,… read more here.
Keywords: protein; corona formation; protein corona; influence nanoparticle ... See more keywords
Tailor-Made Protein Corona Formation on Polystyrene Microparticles and its Effect on Epithelial Cell Uptake.
Sign Up to like & getrecommendations! Published in 2022 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.2c13987
Abstract: Microplastic particles are pollutants in the environment with a potential impact on ecology and human health. As soon as microplastic particles get in contact with complex (biological) environments, they will be covered by an eco-… read more here.
Keywords: cell; protein corona; corona formation;
In Situ Characterization of Protein Corona Formation on Silica Microparticles Using Confocal Laser Scanning Microscopy Combined with Microfluidics.
Sign Up to like & getrecommendations! Published in 2019 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.8b14307
Abstract: In biological fluids, proteins bind to particles, forming so-called protein coronas. Such adsorbed protein layers significantly influence the biological interactions of particles, both in vitro and in vivo. The adsorbed protein layer is generally described… read more here.
Keywords: protein; corona formation; protein corona; microscopy ... See more keywords
Polyglycerol Grafting Shields Nanoparticle from Protein Corona Formation to Avoid Macrophage Uptake.
Sign Up to like & getrecommendations! Published in 2020 at "ACS nano"
DOI: 10.1021/acsnano.0c02289
Abstract: Upon contact with biofluids, proteins are quickly adsorbed onto nanoparticle (NP) surface to form a protein corona, which initiates the opsonization and facilitates the rapid clearance of NP by macrophage uptake. Although polyethylene glycol (PEG)… read more here.
Keywords: macrophage uptake; polyglycerol grafting; corona formation; spectroscopy ... See more keywords
Interaction Kinetics of Individual mRNA-Containing Lipid Nanoparticles with an Endosomal Membrane Mimic: Dependence on pH, Protein Corona Formation, and Lipoprotein Depletion
Sign Up to like & getrecommendations! Published in 2022 at "ACS Nano"
DOI: 10.1021/acsnano.2c04829
Abstract: Lipid nanoparticles (LNPs) have emerged as potent carriers for mRNA delivery, but several challenges remain before this approach can offer broad clinical translation of mRNA therapeutics. To improve their efficacy, a better understanding is required… read more here.
Keywords: corona formation; endosomal membrane; membrane; protein corona ... See more keywords
Understanding the Lipid and Protein Corona Formation on Different Sized Polymeric Nanoparticles
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-57943-6
Abstract: When in contact with biological fluids, nanoparticles dynamically absorb biomolecules like proteins and lipids onto their surface, forming a “corona”. This biocorona is a dynamic and complex structure that determines how host cells respond to… read more here.
Keywords: protein; formation different; different sized; formation ... See more keywords
The timeline of corona formation around silica nanocarriers highlights the role of the protein interactome.
Sign Up to like & getrecommendations! Published in 2017 at "Nanoscale"
DOI: 10.1039/c6nr04765c
Abstract: Magnetic mesoporous silica nanoparticles (M-MSNs) represent promising targeting tools for theranostics. Engineering the interaction of nanoparticles (NPs) with biological systems requires an understanding of protein corona formation around the nanoparticles as this drives the biological… read more here.
Keywords: formation around; corona; timeline corona; role ... See more keywords
Physiology, pathology and the biomolecular corona: the confounding factors in nanomedicine design.
Sign Up to like & getrecommendations! Published in 2022 at "Nanoscale"
DOI: 10.1039/d1nr08101b
Abstract: The biomolecular corona that forms on nanomedicines in different physiological and pathological environments confers a new biological identity. How the recipient biological system's state can potentially affect nanomedicine corona formation, and how this can be… read more here.
Keywords: corona formation; pathology; physiology; biomolecular corona ... See more keywords