Effect of High vs Low Doses of Chloroquine Diphosphate as Adjunctive Therapy for Patients Hospitalized With Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection: A Randomized Clinical Trial.
Sign Up to like & getrecommendations! Published in 2020 at "JAMA network open"
DOI: 10.1001/jamanetworkopen.2020.8857
Abstract: Importance There is no specific antiviral therapy recommended for coronavirus disease 2019 (COVID-19). In vitro studies indicate that the antiviral effect of chloroquine diphosphate (CQ) requires a high concentration of the drug. Objective To evaluate… read more here.
Keywords: dosage group; group; coronavirus; dosage ... See more keywords
Severe Acute Respiratory Syndrome Coronavirus 2 Nucleocapsid Protein in the Ocular Tissues of a Patient Previously Infected With Coronavirus Disease 2019.
Sign Up to like & getrecommendations! Published in 2020 at "JAMA ophthalmology"
DOI: 10.1001/jamaophthalmol.2020.3962
Abstract: Importance Coronavirus disease 2019 (COVID-19) has been recognized as a pandemic by the World Health Organization. Whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can also infect tissues besides the respiratory system, such as the… read more here.
Keywords: ocular tissues; previously infected; nucleocapsid protein; patient previously ... See more keywords
School Closure During the Coronavirus Disease 2019 (COVID-19) Pandemic: An Effective Intervention at the Global Level?
Sign Up to like & getrecommendations! Published in 2020 at "JAMA pediatrics"
DOI: 10.1001/jamapediatrics.2020.1892
Abstract: In most countries, attempts to reduce severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) circulation and new coronavirus disease 2019 (COVID-19) development have been mainly based on restrictive measures, including the avoidance of social interactions, the… read more here.
Keywords: school closure; closure; school; coronavirus ... See more keywords
Targetable Biological Mechanisms Implicated in Emergent Psychiatric Conditions Associated With SARS-CoV-2 Infection.
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DOI: 10.1001/jamapsychiatry.2020.2795
Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in 2019 and then rapidly led to a pandemic with widespread cases of SARS and excess mortality. In response, mitigation efforts (including social distancing, quarantining, and closing… read more here.
Keywords: infection; coronavirus; biological mechanisms; psychiatric conditions ... See more keywords
Gossypol Broadly Inhibits Coronaviruses by Targeting RNA‐Dependent RNA Polymerases (Adv. Sci. 35/2022)
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DOI: 10.1002/advs.202203499
Abstract: Outbreaks of coronaviruses (CoVs), especially severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), have posed serious threats to humans and animals, which urgently calls for effective broad‐spectrum antivirals. RNA‐dependent RNA polymerase (RdRp) plays an essential role… read more here.
Keywords: dependent rna; gossypol broadly; coronavirus; rna dependent ... See more keywords
Host genetic factors and susceptibility to SARS‐CoV‐2 infection
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DOI: 10.1002/ajhb.23497
Abstract: While this article was being written, the novel coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) had infected over 4.48 million people in the United States, and killed over 152 000 of them (CDC COVID… read more here.
Keywords: infection; sironi 2020; coronavirus; biology ... See more keywords
Synthesis and anti‐coronavirus activity of a series of 1‐thia‐4‐azaspiro[4.5]decan‐3‐one derivatives
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DOI: 10.1002/ardp.201800330
Abstract: A series of 1‐thia‐4‐azaspiro[4.5]decan‐3‐ones bearing an amide group at C‐4 and various substitutions at C‐2 and C‐8 were synthesized and evaluated against human coronavirus and influenza virus. Compounds 7m, 7n, 8k, 8l, 8m, 8n, and… read more here.
Keywords: thia azaspiro; azaspiro decan; coronavirus; series thia ... See more keywords
Mental health consequences of infections by coronaviruses including severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2)
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DOI: 10.1002/brb3.1901
Abstract: Anxiety and stress like mental illnesses are the common outcomes of viral epidemics and pandemics. Novel coronavirus disease 2019 (COVID‐19) outbreak caused by the severe acute respiratory syndrome coronavirus virus 2 (SARS‐CoV‐2) was first reported… read more here.
Keywords: respiratory syndrome; severe acute; syndrome coronavirus; coronavirus ... See more keywords
Potential targets of severe acute respiratory syndrome coronavirus 2 of clinical drug fluvoxamine: Docking and molecular dynamics studies to elucidate viral action
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DOI: 10.1002/cbf.3766
Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) has continued evolving for survival and adaptation by mutating itself into different variants of concern, including omicron. Several studies and clinical trials found fluvoxamine, an Food and Drug… read more here.
Keywords: fluvoxamine; severe acute; coronavirus; action ... See more keywords
Cytologic and histologic samples from patients infected by the novel coronavirus 2019 SARS‐CoV‐2: An Italian institutional experience focusing on biosafety procedures
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DOI: 10.1002/cncy.22281
Abstract: The 2019 coronavirus pandemic, which started in Wuhan, China, spread around the globe with dramatic and lethal effects. From the initial Chinese epicenter, the European diaspora taxed the resources of several countries and especially those… read more here.
Keywords: infected novel; cytologic histologic; coronavirus; patients infected ... See more keywords
Dysfunctional coronavirus anxiety in nonpsychotic psychiatric outpatients during the COVID‐19 pandemic: A network analysis
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DOI: 10.1002/da.23256
Abstract: The 2019 coronavirus disease (COVID‐19) pandemic has had a profound impact on the mental health of people worldwide. This study examined dysfunctional coronavirus anxiety in nonpsychotic psychiatric outpatients during the pandemic using the coronavirus anxiety… read more here.
Keywords: dysfunctional coronavirus; coronavirus; coronavirus anxiety; covid pandemic ... See more keywords