Structure-Guided Design of Conformationally Constrained Cyclohexane Inhibitors of Severe Acute Respiratory Syndrome Coronavirus-2 3CL Protease
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DOI: 10.1021/acs.jmedchem.1c00319
Abstract: A series of nondeuterated and deuterated dipeptidyl aldehyde and masked aldehyde inhibitors that incorporate in their structure a conformationally constrained cyclohexane moiety was synthesized and found to potently inhibit severe acute respiratory syndrome coronavirus-2 3CL… read more here.
Keywords: respiratory syndrome; 3cl protease; coronavirus 3cl; syndrome coronavirus ... See more keywords
Identification of novel drug candidates for the inhibition of catalytic cleavage activity of coronavirus 3CL-like protease enzyme.
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DOI: 10.2174/1389201022666210604150041
Abstract: BACKGROUND There has been tremendous pressure on healthcare facilities globally due to the recent emergence of novel coronavirus infections known as COVID-19 and its rapid spread across the continents. The lack of effective therapeutics for… read more here.
Keywords: coronavirus 3cl; cov 3clpro; 3cl like; like protease ... See more keywords