Inhibition of Cytosolic Phospholipase A2α Impairs an Early Step of Coronavirus Replication in Cell Culture
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Virology"
DOI: 10.1128/jvi.01463-17
Abstract: ABSTRACT Coronavirus replication is associated with intracellular membrane rearrangements in infected cells, resulting in the formation of double-membrane vesicles (DMVs) and other membranous structures that are referred to as replicative organelles (ROs). The latter provide… read more here.
Keywords: microscopy; cpla2; phospholipase; coronavirus ... See more keywords
Effects of immunophilin inhibitors and non-immunosuppressive analogs on coronavirus replication in human infection models
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2022.958634
Abstract: Rationale Human coronaviruses (HCoVs) seriously affect human health by causing respiratory diseases ranging from common colds to severe acute respiratory diseases. Immunophilins, including peptidyl-prolyl isomerases of the FK506-binding protein (FKBP) and the cyclophilin family, are… read more here.
Keywords: fk506; replication; infection; coronavirus replication ... See more keywords
Epigallocatechin Gallate (EGCG), a Green Tea Polyphenol, Reduces Coronavirus Replication in a Mouse Model
Sign Up to like & getrecommendations! Published in 2021 at "Viruses"
DOI: 10.3390/v13122533
Abstract: The COVID-19 pandemic has resulted in a huge number of deaths from 2020 to 2021; however, effective antiviral drugs against SARS-CoV-2 are currently under development. Recent studies have demonstrated that green tea polyphenols, particularly EGCG,… read more here.
Keywords: coronavirus replication; replication mouse; green tea; tea ... See more keywords