The triterpenoid corosolic acid blocks transformation and epigenetically reactivates Nrf2 in TRAMP‐C1 prostate cells
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.22776
Abstract: Corosolic acid (CRA) is found in various plants and has been used as a health food supplement worldwide. Although it has been reported that CRA exhibits significant anticancer activity, the effect of this compound on… read more here.
Keywords: prostate; corosolic acid; prostate cells; tramp ... See more keywords
Nrf2 activator corosolic acid meliorates alloxan induced diabetic nephropathy in mice
Sign Up to like & getrecommendations! Published in 2017 at "Asian pacific Journal of Tropical Biomedicine"
DOI: 10.1016/j.apjtb.2017.08.010
Abstract: Abstract Objective To determine whether corosolic acid (CA) targeting nuclear protein expression of Nrf2 activation can be used to attenuate renal damage and preserve renal function in alloxan diabetic mice. Methods A mouse model with… read more here.
Keywords: nrf2 expression; corosolic acid; diabetic nephropathy; mice ... See more keywords
Corosolic acid isolated from Eriobotrya japonica leaves reduces glucose level in human hepatocellular carcinoma cells, zebrafish and rats
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-40934-7
Abstract: Type 2 diabetes (T2D) with high morbidity and mortality is characterized by abnormal glucose and lipid metabolism due in part to insulin resistance in liver, which lead to elevated hyperglycemia and hyperlipidemia. This study sough… read more here.
Keywords: japonica leaves; corosolic acid; eriobotrya japonica; acid isolated ... See more keywords
Vesicular self-assembly of a natural ursane-type dihydroxy-triterpenoid corosolic acid
Sign Up to like & getrecommendations! Published in 2019 at "RSC Advances"
DOI: 10.1039/c9ra02801c
Abstract: Corosolic acid, a natural ursane-type 6-6-6-6-6 pentacyclic dihydroxy triterpenic acid, self-assembled in binary liquid mixtures yielding vesicles. read more here.
Keywords: dihydroxy; ursane type; natural ursane; corosolic acid ... See more keywords
Corosolic acid inhibits tumour growth without compromising associating liver partition and portal vein ligation-induced liver regeneration in rats
Sign Up to like & getrecommendations! Published in 2022 at "Annals of Medicine"
DOI: 10.1080/07853890.2022.2067893
Abstract: Abstract Background Associating liver partition and portal vein ligation (ALPPS) technique is a promising strategy for unresectable primary liver tumours without sufficient future liver remnants (FLRs). Objective Our study explored the effect of corosolic acid… read more here.
Keywords: regeneration; corosolic acid; growth; liver regeneration ... See more keywords
Corosolic Acid Inhibits Secretory Phospholipase A2IIa as an Anti-Inflammatory Function and Exhibits Anti-Tumor Activity in Ehrlich Ascites Carcinoma Bearing Mice
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Inflammation Research"
DOI: 10.2147/jir.s383441
Abstract: Background Inflammation is generally connected to tumour progression and development. The secretory phospholipase A2IIa (sPLA2IIa) is an important inflammatory enzyme that catalyse the hydrolysis of membrane phospholipids into arachidonic and lysophosphatidic acid, which are the… read more here.
Keywords: spla2iia; corosolic acid; anti inflammatory; activity ... See more keywords
An in vitro investigation of the apoptosis-inducing activity of corosolic acid in breast cancer cells
Sign Up to like & getrecommendations! Published in 2023 at "Iranian Journal of Basic Medical Sciences"
DOI: 10.22038/ijbms.2023.67783.14834
Abstract: Objective(s): Breast cancer is the most prevalent cancer among females with different molecular subtypes. Corosolic acid is a pentacyclic triterpenoid with anti-cancer properties. Materials and Methods: The MTT assay was used to assess the cytotoxic… read more here.
Keywords: breast cancer; apoptosis; corosolic acid;
Characterization of Corosolic Acid as a KPC-2 Inhibitor That Increases the Susceptibility of KPC-2-Positive Bacteria to Carbapenems
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2020.01047
Abstract: The emergence of KPC-producing Gram-negative bacteria in clinical practice highlights the need to search for novel antimicrobials and new anti-infection strategies. In this study, we constructed a laboratory KPC-2-positive strain, E. coli BL21(DE3) (pET28a-KPC-2) and… read more here.
Keywords: corosolic acid; positive bacteria; characterization corosolic; kpc ... See more keywords
Neuroprotective Effect of Corosolic Acid Against Cerebral Ischemia-Reperfusion Injury in Experimental Rats.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of oleo science"
DOI: 10.5650/jos.ess22130
Abstract: Several therapeutic approaches were also urgently needed as ischaemic stroke was one of the most common brain disorders. Many phytochemicals have recently been discovered for the advancement of leadlike libraries that are concentrated on the… read more here.
Keywords: corosolic acid; experimental rats; brain; injury ... See more keywords