Selective loading and processing of prespacers for precise CRISPR adaptation
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DOI: 10.1038/s41586-020-2018-1
Abstract: CRISPR–Cas immunity protects prokaryotes against invading genetic elements 1 . It uses the highly conserved Cas1–Cas2 complex to establish inheritable memory (spacers) 2 – 5 . How Cas1–Cas2 acquires spacers from foreign DNA fragments (prespacers)… read more here.
Keywords: pam sequence; correct orientation; integration; cas1 cas2 ... See more keywords