Integrated structural variation and point mutation signatures in cancer genomes using correlated topic models
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DOI: 10.1371/journal.pcbi.1006799
Abstract: Mutation signatures in cancer genomes reflect endogenous and exogenous mutational processes, offering insights into tumour etiology, features for prognostic and biologic stratification and vulnerabilities to be exploited therapeutically. We present a novel machine learning formalism… read more here.
Keywords: correlated topic; mutation signatures; signatures cancer; cancer ... See more keywords