Immune correlates of protection for dengue: State of the art and research agenda.
Sign Up to like & getrecommendations! Published in 2017 at "Vaccine"
DOI: 10.1016/j.vaccine.2017.07.045
Abstract: Dengue viruses (DENV1-4) are mosquito-borne flaviviruses estimated to cause up to ∼400 million infections and ∼100 million dengue cases each year. Factors that contribute to protection from and risk of dengue and severe dengue disease… read more here.
Keywords: dengue; research agenda; correlates protection; immune correlates ... See more keywords
Humoral and cellular immune correlates of protection against bubonic plague by a live Yersinia pseudotuberculosis vaccine.
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DOI: 10.1016/j.vaccine.2018.11.022
Abstract: Immunization with the live-attenuated Yersinia pseudotuberculosis VTnF1 strain producing a Yersinia pestis F1 pseudocapsule efficiently protects mice against bubonic and pneumonic plague. In clinical trials, demonstration of a plague vaccine's efficacy in humans will not… read more here.
Keywords: protection; correlates protection; plague; humoral cellular ... See more keywords
Evaluation of correlates of protection against influenza A(H3N2) and A(H1N1)pdm09 infection: Applications to the hospitalized patient population.
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DOI: 10.1016/j.vaccine.2019.01.055
Abstract: BACKGROUND Influenza vaccines are important for prevention of influenza-associated hospitalization. However, the effectiveness of influenza vaccines can vary by year and influenza type and subtype and mechanisms underlying this variation are incompletely understood. Assessments of… read more here.
Keywords: correlates protection; pdm09 infection; h1n1 pdm09; infection ... See more keywords
Correlates of protection against Neisseria Meningitidis
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DOI: 10.1038/nri.2016.135
Abstract: Andrew Pollard describes a 1921 study by George Heist and colleagues that pointed to antibody as a correlate of protection against meningococcal disease. read more here.
Keywords: protection; correlates protection; neisseria meningitidis; protection neisseria ... See more keywords
Immunological surrogate endpoints of COVID-2019 vaccines: the evidence we have versus the evidence we need
Sign Up to like & getrecommendations! Published in 2021 at "Signal Transduction and Targeted Therapy"
DOI: 10.1038/s41392-021-00481-y
Abstract: In response to the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic, over 200 vaccine candidates against coronavirus disease 2019 (COVID-2019) are under development and currently moving forward at an unparalleled speed. The availability of surrogate… read more here.
Keywords: covid 2019; surrogate endpoints; correlates protection; evidence ... See more keywords
Correlates of protection against SARS‐CoV‐2 infection and COVID‐19 disease
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DOI: 10.1111/imr.13091
Abstract: Antibodies against epitopes in S1 give the most accurate CoP against infection by the SARS‐CoV‐2 coronavirus. Measurement of those antibodies by neutralization or binding assays both have predictive value, with binding antibody titers giving the… read more here.
Keywords: protection sars; infection covid; infection; correlates protection ... See more keywords
Mapping functional humoral correlates of protection against malaria challenge following RTS,S/AS01 vaccination
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DOI: 10.1126/scitranslmed.abb4757
Abstract: A combination of two Fc antibody features that leverage innate immune function predicts protection from malaria challenge after RTS,S/AS01 vaccination. Above and beyond antibody abundance Vaccine development can be hampered by a lack of clear… read more here.
Keywords: protection; correlates protection; rts as01; serology ... See more keywords
Comparing antibody assays as correlates of protection against COVID-19 in the COVE mRNA-1273 vaccine efficacy trial
Sign Up to like & getrecommendations! Published in 2023 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.ade9078
Abstract: The best assay or marker to define mRNA-1273 vaccine–induced antibodies as a correlate of protection (CoP) is unclear. In the COVE trial, participants received two doses of the mRNA-1273 COVID-19 vaccine or placebo. We previously… read more here.
Keywords: protection; mrna 1273; 1273 vaccine; correlates protection ... See more keywords
Vaccination With Sporozoites: Models and Correlates of Protection
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DOI: 10.3389/fimmu.2019.01227
Abstract: Despite continuous efforts, the century-old goal of eradicating malaria still remains. Multiple control interventions need to be in place simultaneously to achieve this goal. In addition to effective control measures, drug therapies and insecticides, vaccines… read more here.
Keywords: correlates protection; vaccination sporozoites; models correlates; vaccination ... See more keywords
Immune correlates of protection for SARS-CoV-2, Ebola and Nipah virus infection
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1156758
Abstract: Correlates of protection (CoP) are biological parameters that predict a certain level of protection against an infectious disease. Well-established correlates of protection facilitate the development and licensing of vaccines by assessing protective efficacy without the… read more here.
Keywords: protection; infection; correlates protection; immune correlates ... See more keywords
Modelling the response to vaccine in non-human primates to define SARS-CoV-2 mechanistic correlates of protection
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DOI: 10.7554/elife.75427
Abstract: The definition of correlates of protection is critical for the development of next-generation SARS-CoV-2 vaccine platforms. Here, we propose a model-based approach for identifying mechanistic correlates of protection based on mathematical modelling of viral dynamics… read more here.
Keywords: mechanistic correlates; protection; correlates protection; vaccine ... See more keywords