Initial correlative studies from a trial of cetuximab and pembrolizumab in metastatic colorectal cancer (mCRC).
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2020.38.15_suppl.4062
Abstract: 4062Background: Cetuximab is an EGFR-targeting IgG1 mAb. Pre-clinical data suggests cetuximab induces CD8+ cytotoxic T-cell (CTL) infiltration of tumors. We hypothesized that augmentation of CTLs i... read more here.
Keywords: cetuximab pembrolizumab; correlative studies; cetuximab; initial correlative ... See more keywords
A multiplexed assay for quantifying immunomodulatory proteins supports correlative studies in immunotherapy clinical trials
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2023.1168710
Abstract: Introduction Immunotherapy is an effective treatment for a subset of cancer patients, and expanding the benefits of immunotherapy to all cancer patients will require predictive biomarkers of response and immune-related adverse events (irAEs). To support… read more here.
Keywords: immunomodulatory proteins; immunotherapy clinical; studies immunotherapy; clinical trials ... See more keywords