Quantitative analysis of 11‐dehydrocorticosterone and corticosterone for preclinical studies by liquid chromatography/triple quadrupole mass spectrometry
Sign Up to like & getrecommendations! Published in 2019 at "Rapid Communications in Mass Spectrometry"
DOI: 10.1002/rcm.8610
Abstract: Rationale The activity of the glucocorticoid activating enzyme 11β‐hydroxysteroid dehydrogenase type‐1 (11βHSD1) is altered in diseases such as obesity, inflammation and psychiatric disorders. In rodents 11βHSD1 converts inert 11‐dehydrocorticosterone (11‐DHC) into the active form, corticosterone… read more here.
Keywords: mass spectrometry; analysis; cort; dhc ... See more keywords
Neuroprotective evidence of alpha-lipoic acid and desvenlafaxine on memory deficit in a neuroendocrine model of depression
Sign Up to like & getrecommendations! Published in 2018 at "Naunyn-Schmiedeberg's Archives of Pharmacology"
DOI: 10.1007/s00210-018-1509-1
Abstract: Cognitive impairment is present in patients with depression. We hypothesized that alpha-lipoic acid (ALA) can reduce cognitive impairment, especially when combined to antidepressants. Female mice received vehicle or corticosterone (CORT) 20 mg/kg, s.c. for 14 days. From… read more here.
Keywords: depression; dvs20; cort; alpha lipoic ... See more keywords
Examining the Effects of Chronic Selenium Exposure on Traditionally Used Stress Parameters in Juvenile American Alligators (Alligator mississippiensis)
Sign Up to like & getrecommendations! Published in 2019 at "Archives of Environmental Contamination and Toxicology"
DOI: 10.1007/s00244-019-00626-9
Abstract: Environmental contaminants, such as the trace element selenium (Se), are a continuing concern to species worldwide due to their potential pathophysiological effects, including their influence on the stress response mediated through glucocorticoids (GCs; stress hormones).… read more here.
Keywords: used stress; exposure; traditionally used; cort ... See more keywords
Nrf2 Signaling Pathway Mediates the Antioxidative Effects of Taurine Against Corticosterone-Induced Cell Death in HUMAN SK-N-SH Cells
Sign Up to like & getrecommendations! Published in 2017 at "Neurochemical Research"
DOI: 10.1007/s11064-017-2419-1
Abstract: Substantial evidence has shown that elevated circulating corticosteroids or chronic stress contributes to neuronal cell death, cognitive and mental disorders. However, the underlying mechanism is still unclear. Taurine is considered to protect neuronal cells from… read more here.
Keywords: effects taurine; cell; cort; cell death ... See more keywords
Novelty induces behavioural and glucocorticoid responses in a songbird artificially selected for divergent personalities
Sign Up to like & getrecommendations! Published in 2017 at "Animal Behaviour"
DOI: 10.1016/j.anbehav.2017.06.028
Abstract: Stress physiology is thought to contribute to individual differences in behaviour. In part this reflects the fact that canonical personality measures consist of responses to challenges, including novel objects and environments. Exposure to novelty is… read more here.
Keywords: selected divergent; exposure; selection; cort ... See more keywords
Novel markers of inflammation and their relevance to depression: The unique relation of the Neutrophil: Lymphocyte Ratio (NLR) and the Cortisol:C-reactive protein (CORT/CRP) ratio to an intermediate phenotype of Major Depressive Disorders (MDD)
Sign Up to like & getrecommendations! Published in 2017 at "Brain, Behavior, and Immunity"
DOI: 10.1016/j.bbi.2017.07.053
Abstract: We have shown that low CORT/CRP ratio values, suggestive of enhanced inflammation with attenuated CORT release, predict negative affect (NA) reactivity to stress but only among adults with elevated depressive symptoms. The NLR is another… read more here.
Keywords: depression; ratio; crp ratio; cort ... See more keywords
Glucocorticoids mediate stress induction of the alarmin HMGB1 and reduction of the microglia checkpoint receptor CD200R1 in limbic brain structures
Sign Up to like & getrecommendations! Published in 2019 at "Brain, Behavior, and Immunity"
DOI: 10.1016/j.bbi.2019.05.014
Abstract: Exposure to stressors primes neuroinflammatory responses to subsequent immune challenges and stress-induced glucocorticoids (GCs) play a mediating role in this phenomenon of neuroinflammatory priming. Recent evidence also suggests that the alarmin high-mobility group box-1 (HMGB1)… read more here.
Keywords: hmgb1; effects stress; cd200r1; cort ... See more keywords
Altered acoustic startle, prepulse facilitation, and object recognition memory produced by corticosterone withdrawal in male rats
Sign Up to like & getrecommendations! Published in 2021 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2021.113291
Abstract: The symptoms of human depression often include cognitive deficits. However, cognition is not frequently included in the behavioral assessments conducted in preclinical models of depression. For example, it is well known that repeated corticosterone (CORT)… read more here.
Keywords: cort; recognition memory; corticosterone; object recognition ... See more keywords
Chronic exposure to glucocorticoids induces suboptimal decision-making in mice
Sign Up to like & getrecommendations! Published in 2021 at "European Neuropsychopharmacology"
DOI: 10.1016/j.euroneuro.2021.01.094
Abstract: Anxio-depressive symptoms as well as severe cognitive dysfunction including aberrant decision-making (DM) are documented in neuropsychiatric patients with hypercortisolaemia. Yet, the influence of the hypothalamo-pituitary-adrenal (HPA) axis on DM processes remains poorly understood. As a… read more here.
Keywords: induces suboptimal; cort; glucocorticoids induces; decision making ... See more keywords
Dissociable roles of glucocorticoid and noradrenergic activation on social discounting
Sign Up to like & getrecommendations! Published in 2018 at "Psychoneuroendocrinology"
DOI: 10.1016/j.psyneuen.2018.01.015
Abstract: People often exhibit prosocial tendencies towards close kin and friends, but generosity decreases as a function of increasing social distance between donor and recipient, a phenomenon called social discounting. Evidence suggests that acute stress affects… read more here.
Keywords: social discounting; cort; stress; discounting ... See more keywords
Testicular induced corticosterone synthesis in male rats under fasting stress
Sign Up to like & getrecommendations! Published in 2022 at "Steroids"
DOI: 10.1016/j.steroids.2021.108947
Abstract: Testicular steroidogenesis is depressed by adrenal-secreted corticosterone (CORT) under stress. However, the mechanisms are not well understood. This study investigated the details of testicular steroidogenesis depression during fasting. Blood levels of adrenocorticotropic hormone secreted from… read more here.
Keywords: testicular steroidogenesis; cort; fasting stress; synthesis ... See more keywords