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Knockout of the circadian gene, Per2, disrupts corticosterone secretion and results in depressiveā€like behaviors and deficits in startle responses

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Published in 2021 at "BMC Neuroscience"

DOI: 10.1186/s12868-020-00607-y

Abstract: Background The Period Circadian Regulator 2 ( Per2 ) gene is important for the modulation of circadian rhythms that influence biological processes. Circadian control of the hypothalamus-pituitary-adrenal (HPA) axis is critical for regulation of hormones… read more here.

Keywords: per2; hpa axis; like behaviors; depressive like ... See more keywords