Epigenetic control of region‐specific transcriptional programs in mouse cerebellar and cortical astrocytes
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DOI: 10.1002/glia.24016
Abstract: Astrocytes from the cerebral cortex (CTX) and cerebellum (CB) share basic molecular programs, but also form distinct spatial and functional subtypes. The regulatory epigenetic layers controlling such regional diversity have not been comprehensively investigated so… read more here.
Keywords: transcriptional programs; region specific; epigenetic control; cortical astrocytes ... See more keywords
GPR37L1 controls maturation and organization of cortical astrocytes during development.
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DOI: 10.1002/glia.24375
Abstract: Astrocyte maturation is crucial to proper brain development and function. This maturation process includes the ramification of astrocytic morphology and the establishment of astrocytic domains. While this process has been well-studied, the mechanisms by which… read more here.
Keywords: cortical astrocytes; maturation; development; gpr37l1 ... See more keywords
The roles of cortical astrocytes in chronic pain and other brain pathologies
Sign Up to like & getrecommendations! Published in 2018 at "Neuroscience Research"
DOI: 10.1016/j.neures.2017.08.009
Abstract: Astrocytes are the most abundant cell type in the brain. Several decades ago, they were considered to be only support cells in the central nervous system. Recent studies using advanced technologies have clarified that astrocytes… read more here.
Keywords: brain pathologies; roles cortical; cortical astrocytes; brain ... See more keywords
Tropism of SARS-CoV-2 for human cortical astrocytes
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2122236119
Abstract: Significance Neurological and neuropsychiatric symptoms occur in as many as one-third of patients with or recovering from COVID-19. To address severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) neural tropism, we evaluated the vulnerability of primary… read more here.
Keywords: cortical astrocytes; infection; human cortical; tropism sars ... See more keywords
Unconjugated bilirubin induces pyroptosis in cultured rat cortical astrocytes
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Neuroinflammation"
DOI: 10.1186/s12974-018-1064-1
Abstract: BackgroundBilirubin-induced neurological dysfunction (BIND), a severe complication of extreme neonatal hyperbilirubinemia, could develop into permanent neurodevelopmental impairments. Several studies have demonstrated that inflammation and nerve cell death play important roles in bilirubin-induced neurotoxicity; however, the… read more here.
Keywords: rat cortical; pyroptosis; unconjugated bilirubin; cortical astrocytes ... See more keywords
Differential Proliferation and Maturation of Subcortical Astrocytes During Postnatal Development
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DOI: 10.3389/fnins.2020.00435
Abstract: Astrocytes exhibit a region-dependent molecular and functional heterogeneity in the CNS. Although cortical astrocytes proliferate robustly during the first postnatal week and become proliferation quiescent, the temporal proliferation dynamics of astrocytes in subcortical regions during… read more here.
Keywords: astrocytes postnatal; proliferation; cortical astrocytes; maturation ... See more keywords
Metabolic Heterogeneity of Cerebral Cortical and Cerebellar Astrocytes
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DOI: 10.3390/life13010184
Abstract: Astrocytes play critical roles in regulating neuronal synaptogenesis, maintaining blood–brain barrier integrity, and recycling neurotransmitters. Increasing numbers of studies have suggested astrocyte heterogeneity in morphology, gene profile, and function. However, metabolic phenotype of astrocytes in… read more here.
Keywords: cerebellar astrocytes; cortical astrocytes; metabolic heterogeneity; cortical cerebellar ... See more keywords