Developmental characterization of Zswim5 expression in the progenitor domains and tangential migration pathways of cortical interneurons in the mouse forebrain
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Comparative Neurology"
DOI: 10.1002/cne.24900
Abstract: GABAergic interneurons play an essential role in modulating cortical networks. The progenitor domains of cortical interneurons are localized in developing ventral forebrain, including the medial ganglionic eminence (MGE), caudal ganglionic eminence (CGE), preoptic area (POA),… read more here.
Keywords: zswim5 expression; tangential migration; cortical interneurons; zswim5 ... See more keywords
Cortical Interneurons Differentially Regulate the Effects of Acoustic Context.
Sign Up to like & getrecommendations! Published in 2017 at "Cell reports"
DOI: 10.1016/j.celrep.2017.07.001
Abstract: Both behavioral and neural responses to sounds are generally modified by the acoustic context in which they are encountered. As an example, in the auditory cortex, preceding sounds can powerfully suppress responses to later, spectrally similar… read more here.
Keywords: suppression; forward suppression; cortical interneurons; acoustic context ... See more keywords
PDK1 regulates the survival of the developing cortical interneurons
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Brain"
DOI: 10.1186/s13041-020-00604-6
Abstract: Inhibitory interneurons are critical for maintaining the excitatory/inhibitory balance. During the development cortical interneurons originate from the ganglionic eminence and arrive at the dorsal cortex through two tangential migration routes. However, the mechanisms underlying the… read more here.
Keywords: cortical interneurons; developing cortical; regulates survival; survival developing ... See more keywords
Transcription Factors Sp8 and Sp9 Regulate Medial Ganglionic Eminence-Derived Cortical Interneuron Migration
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2019.00075
Abstract: Cortical interneurons are derived from the subpallium and reach the developing cortex through long tangential migration. Mature cortical interneurons are characterized by remarkable morphological, molecular, and functional diversity. The calcium-binding protein parvalbumin (PV) and neuropeptide… read more here.
Keywords: cortical interneurons; cortical interneuron; derived cortical; migration ... See more keywords
Inhibitory synapse dysfunction and epileptic susceptibility associated with KIF2A deletion in cortical interneurons
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2022.1110986
Abstract: Malformation of cortical development (MCD) is a family of neurodevelopmental disorders, which usually manifest with intellectual disability and early-life epileptic seizures. Mutations in genes encoding microtubules (MT) and MT-associated proteins are one of the most… read more here.
Keywords: synapse dysfunction; deletion; dysfunction epileptic; susceptibility ... See more keywords
Loss of KCC2 in GABAergic Neurons Causes Seizures and an Imbalance of Cortical Interneurons
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2022.826427
Abstract: K-Cl transporter KCC2 is an important regulator of neuronal development and neuronal function at maturity. Through its canonical transporter role, KCC2 maintains inhibitory responses mediated by γ-aminobutyric acid (GABA) type A receptors. During development, late… read more here.
Keywords: imbalance cortical; gabaergic neurons; loss kcc2; kcc2 ... See more keywords