In vivo assessment of iron content of the cerebral cortex in healthy aging using 7-Tesla T2*-weighted phase imaging
Sign Up to like & getrecommendations! Published in 2017 at "Neurobiology of Aging"
DOI: 10.1016/j.neurobiolaging.2016.09.005
Abstract: Accumulation of brain iron has been suggested as a biomarker of neurodegeneration. Increased iron has been seen in the cerebral cortex in postmortem studies of neurodegenerative diseases and healthy aging. Until recently, the diminutive thickness… read more here.
Keywords: phase; healthy aging; cerebral cortex; iron content ... See more keywords
Cortical iron accumulation in MAPT- and C9orf 72-associated frontotemporal lobar degeneration.
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DOI: 10.1111/bpa.13158
Abstract: Neuroinflammation has been implicated in frontotemporal lobar degeneration (FTLD) pathophysiology, including in genetic forms with microtubule-associated protein tau (MAPT) mutations (FTLD-MAPT) or chromosome 9 open reading frame 72 (C9orf72) repeat expansions (FTLD-C9orf72). Iron accumulation as a… read more here.
Keywords: ftld mapt; iron; cortical iron; iron accumulation ... See more keywords
Associations of cortical iron accumulation with cognition and cerebral atrophy in Alzheimer’s disease
Sign Up to like & getrecommendations! Published in 2022 at "Quantitative Imaging in Medicine and Surgery"
DOI: 10.21037/qims-22-7
Abstract: Background In Alzheimer’s disease (AD), cerebral iron accumulation colocalizes with the pathological proteins amyloid-β (Aβ) and tau. Furthermore, tau-induced cortical thinning is associated with cognitive decline. In this study, quantitative susceptibility mapping (QSM) was used… read more here.
Keywords: cortical iron; whole brain; iron; susceptibility ... See more keywords