Cux2 expression regulated by Lhx2 in the upper layer neurons of the developing cortex.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.11.004
Abstract: The laminar structure, a unique feature of the mammalian cerebrum, is formed by a number of genes in a highly complex process. The pyramidal neurons that make up each layer of the cerebrum are functionally… read more here.
Keywords: expression regulated; layer neurons; cortical layer; expression ... See more keywords
Neonatal Tbr1 Dosage Controls Cortical Layer 6 Connectivity
Sign Up to like & getrecommendations! Published in 2018 at "Neuron"
DOI: 10.1016/j.neuron.2018.09.027
Abstract: An understanding of how heterozygous loss-of-function mutations in autism spectrum disorder (ASD) risk genes, such as TBR1, contribute to ASD remains elusive. Conditional Tbr1 deletion during late mouse gestation in cortical layer 6 neurons (Tbr1layer6… read more here.
Keywords: tbr1 dosage; cortical layer; layer; neonatal tbr1 ... See more keywords
Upper cortical layer–driven network impairment in schizophrenia
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abn8367
Abstract: Schizophrenia is one of the most widespread and complex mental disorders. To characterize the impact of schizophrenia, we performed single-nucleus RNA sequencing (snRNA-seq) of >220,000 neurons from the dorsolateral prefrontal cortex of patients with schizophrenia… read more here.
Keywords: upper cortical; cortical layer; layer; network impairment ... See more keywords