Expression of the transcription factor PU.1 induces the generation of microglia-like cells in human cortical organoids
Sign Up to like & getrecommendations! Published in 2022 at "Nature Communications"
DOI: 10.1038/s41467-022-28043-y
Abstract: Microglia play a role in the emergence and preservation of a healthy brain microenvironment. Dysfunction of microglia has been associated with neurodevelopmental and neurodegenerative disorders. Investigating the function of human microglia in health and disease… read more here.
Keywords: transcription factor; cortical organoids; expression; human cortical ... See more keywords
Direct Generation of Human Cortical Organoids from Primary Cells.
Sign Up to like & getrecommendations! Published in 2018 at "Stem cells and development"
DOI: 10.1089/scd.2018.0112
Abstract: The study of variations in human neurodevelopment and cognition is limited by the availability of experimental models. While animal models only partially recapitulate the human brain development, genetics, and heterogeneity, human-induced pluripotent stem cells can… read more here.
Keywords: direct generation; human cortical; generation human; cortical organoids ... See more keywords
Electrophysiological Properties of Human Cortical Organoids: Current State of the Art and Future Directions
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2022.839366
Abstract: Human cortical development is an intricate process resulting in the generation of many interacting cell types and long-range connections to and from other brain regions. Human stem cell-derived cortical organoids are now becoming widely used… read more here.
Keywords: cortical organoids; properties human; electrophysiological properties; human cortical ... See more keywords
The generation and properties of human cortical organoids as a disease model for malformations of cortical development
Sign Up to like & getrecommendations! Published in 2023 at "Neural Regeneration Research"
DOI: 10.4103/1673-5374.369100
Abstract: As three-dimensional “organ-like” aggregates, human cortical organoids have emerged as powerful models for studying human brain evolution and brain disorders with unique advantages of human-specificity, fidelity and manipulation. Human cortical organoids derived from human pluripotent… read more here.
Keywords: malformations cortical; development; human cortical; cortical development ... See more keywords