Serum parathyroid hormone is associated with increased cortical porosity of the inner transitional zone at the proximal femur in postmenopausal women: the Tromsø Study
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DOI: 10.1007/s00198-017-4298-3
Abstract: SummarySerum parathyroid hormone (PTH) was associated with increased bone turnover markers and cortical porosity of the inner transitional zone at the proximal femur. These results suggest that PTH through increased intracortical bone turnover leads to… read more here.
Keywords: porosity; pth associated; bone; associated increased ... See more keywords
Reversing cortical porosity: Cortical pore infilling in preclinical models of chronic kidney disease.
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DOI: 10.1016/j.bone.2020.115632
Abstract: PURPOSE Chronic kidney disease (CKD) patients have a high incidence of fracture due in part to cortical porosity. The goal of this study was to study cortical pore infilling utilizing two rodent models of progressive… read more here.
Keywords: porosity; chronic kidney; cortical porosity; pore infilling ... See more keywords
Evocalcet Rescues Secondary Hyperparathyroidism-driven Cortical Porosity in CKD Male Rats
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DOI: 10.1210/endocr/bqad022
Abstract: Abstract To elucidate the effect of evocalcet, a new oral calcimimetic to bone of secondary hyperparathyroidism (SHPT) with chronic kidney disease (CKD), the rats were 5/6 nephrectomized and fed on a high-phosphate diet. The treated… read more here.
Keywords: shpt rats; porosity ckd; cortical porosity; porosity ... See more keywords
Denosumab treatment is associated with decreased cortical porosity and increased bone density and strength at the proximal humerus of ovariectomized cynomolgus monkeys.
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DOI: 10.2139/ssrn.4045829
Abstract: Upper extremity fractures, including those at the humerus, are common among women with postmenopausal osteoporosis. Denosumab was shown to reduce humeral fractures in this population; however, no clinical or preclinical studies have quantified the effects… read more here.
Keywords: strength; density; cortical porosity; bone ... See more keywords