PKCĪ³ and PKCĪµ are Differentially Activated and Modulate Neurotoxic Signaling Pathways During Oxygen Glucose Deprivation in Rat Cortical Slices
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DOI: 10.1007/s11064-019-02876-4
Abstract: Cerebral ischemia is known to trigger a series of intracellular events such as changes in metabolism, membrane function and intracellular transduction, which eventually leads to cell death. Many of these processes are mediated by intracellular… read more here.
Keywords: glucose deprivation; cortical slices; oxygen glucose; pkc ... See more keywords
S-Allylcysteine Protects Against Excitotoxic Damage in Rat Cortical Slices Via Reduction of Oxidative Damage, Activation of Nrf2/ARE Binding, and BDNF Preservation
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DOI: 10.1007/s12640-020-00260-7
Abstract: Neuroprotective approaches comprising different mechanisms to counteract the noxious effects of excitotoxicity and oxidative stress need validation and detailed characterization. Although S-allylcysteine (SAC) is a natural compound exhibiting a broad spectrum of protective effects characterized… read more here.
Keywords: rat cortical; cortical slices; preservation; nrf2 binding ... See more keywords
Aging protects rat cortical slices against to oxygen-glucose deprivation induced damage
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DOI: 10.1080/00207454.2020.1730830
Abstract: Abstract Objective: In present study, we aimed to clarify effect of aging on the susceptibility of brain tissue to neurodegeneration induced by ischemia. Methods: Damage induced by oxygen-glucose deprivation (OGD) followed by reoxygenation (REO) were… read more here.
Keywords: slices oxygen; ogd reo; rat cortical; glucose deprivation ... See more keywords