Activation of pial and dural macrophages and dendritic cells by cortical spreading depression
Sign Up to like & getrecommendations! Published in 2018 at "Annals of Neurology"
DOI: 10.1002/ana.25169
Abstract: Cortical spreading depression (CSD) has long been implicated in migraine attacks with aura. The process by which CSD, a cortical event that occurs within the blood–brain barrier (BBB), results in nociceptor activation outside the BBB… read more here.
Keywords: activation pial; cortical spreading; spreading depression; bbb ... See more keywords
Cortical Spreading Depolarizations in a Mouse Model of Subarachnoid Hemorrhage
Sign Up to like & getrecommendations! Published in 2022 at "Neurocritical Care"
DOI: 10.1007/s12028-021-01397-9
Abstract: Background Cortical spreading depolarizations (CSDs) are associated with worse outcomes in patients with aneurysmal subarachnoid hemorrhage (SAH). Animal models are required to assess whether CSDs can worsen outcomes or are an epiphenomenon; however, little is… read more here.
Keywords: cortical spreading; mice; injection; csds ... See more keywords
Numerical Simulation of Concussive-Generated Cortical Spreading Depolarization to Optimize DC-EEG Electrode Spacing for Noninvasive Visual Detection
Sign Up to like & getrecommendations! Published in 2022 at "Neurocritical Care"
DOI: 10.1007/s12028-021-01430-x
Abstract: Cortical spreading depolarization (SD) is a propagating depolarization wave of neurons and glial cells in the cerebral gray matter. SD occurs in all forms of severe acute brain injury, as documented by using invasive detection… read more here.
Keywords: cortical spreading; electrode; depolarization; detection ... See more keywords
Macro scale modelling of cortical spreading depression and the role of astrocytic gap junctions.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of theoretical biology"
DOI: 10.1016/j.jtbi.2018.09.006
Abstract: Neuronal activity evokes a localised increase in cerebral blood flow in a response known as neurovascular coupling (NVC), achieved through communication between a group of cells known as a neurovascular unit (NVU). Dysfunctional NVC can… read more here.
Keywords: gap; gap junctions; spreading depression; model ... See more keywords
The effects of cerebral curvature on cortical spreading depression.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of theoretical biology"
DOI: 10.1016/j.jtbi.2019.04.006
Abstract: Neuronal activity evokes a localised increase in cerebral blood flow through neurovascular coupling (NVC), a communication system between a group of cells known as a neurovascular unit (NVU). Dysfunctional NVC can lead to pathologies such… read more here.
Keywords: wave segments; spreading depression; diffusion rate; cortical spreading ... See more keywords
The potential of substance P to initiate and perpetuate cortical spreading depression (CSD) in rat in vivo
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-36330-2
Abstract: The tachykinin substance P (SP) increases neuronal excitability, participates in homeostatic control, but induces brain oedema after stroke or trauma. We asked whether SP is able to induce cortical spreading depression (CSD) which often aggravates… read more here.
Keywords: substance; spreading depression; depression csd; csds ... See more keywords
Kcnq2/Kv7.2 controls the threshold and bi-hemispheric symmetry of cortical spreading depolarization
Sign Up to like & getrecommendations! Published in 2021 at "Brain"
DOI: 10.1093/brain/awab141
Abstract: Abstract Spreading depolarization is a slowly propagating wave of massive cellular depolarization associated with acute brain injury and migraine aura. Genetic studies link depolarizing molecular defects in Ca2+ flux, Na+ current in interneurons, and glial… read more here.
Keywords: spreading depolarization; depolarization; cortical spreading; kcnq2 kv7 ... See more keywords
Determinants of Optogenetic Cortical Spreading Depolarizations
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DOI: 10.1093/cercor/bhy021
Abstract: &NA; Cortical spreading depolarization (SD) is the electrophysiological event underlying migraine aura, and a critical contributor to secondary damage after brain injury. Experimental models of SD have been used for decades in migraine and brain… read more here.
Keywords: determinants optogenetic; spreading depolarizations; injury; cortical spreading ... See more keywords
Vagus nerve stimulation inhibits cortical spreading depression exclusively via central mechanisms.
Sign Up to like & getrecommendations! Published in 2020 at "Pain"
DOI: 10.1097/j.pain.0000000000001856
Abstract: Experimental and clinical data strongly support vagus nerve stimulation (VNS) as a novel treatment in migraine. VNS acutely suppresses cortical spreading depression (CSD) susceptibility, an experimental model that has been used to screen for migraine… read more here.
Keywords: spreading depression; nerve stimulation; stimulation; vagus nerve ... See more keywords
The CGRP receptor antagonist BIBN4096 inhibits prolonged meningeal afferent activation evoked by brief local K+ stimulation but not cortical spreading depression-induced afferent sensitization
Sign Up to like & getrecommendations! Published in 2018 at "Pain Reports"
DOI: 10.1097/pr9.0000000000000632
Abstract: Introduction: Cortical spreading depression (CSD) is believed to promote migraine headache by enhancing the activity and mechanosensitivity of trigeminal intracranial meningeal afferents. One putative mechanism underlying this afferent response involves an acute excitation of meningeal… read more here.
Keywords: spreading depression; cgrp; activation; meningeal ... See more keywords
Transient loss of interhemispheric functional connectivity following unilateral cortical spreading depression in awake rats
Sign Up to like & getrecommendations! Published in 2020 at "Cephalalgia"
DOI: 10.1177/0333102420970172
Abstract: Objective Growing evidence shows a critical role of network disturbances in the pathogenesis of migraine. Unilateral pattern of neurological symptoms of aura suggests disruption of interhemispheric interactions during the early phase of a migraine attack.… read more here.
Keywords: unilateral cortical; cortical spreading; spreading depression; functional connectivity ... See more keywords