Cortical Tension Drives Pluripotent Inner Mass Formation in the Mammalian Embryo
Sign Up to like & getrecommendations! Published in 2017 at "Mechanisms of Development"
DOI: 10.1016/j.mod.2017.04.078
Abstract: Apoptotic extrusion is a process, where junctional contractility is spatially regulated at a supracellular scale to expel a dying cell from the epithelial sheet. During apoptotic extrusion, E-cadherin based cell coupling transduces forces from the… read more here.
Keywords: cortical tension; drives pluripotent; tension drives; extrusion ... See more keywords
Cdk1-mediated DIAPH1 phosphorylation maintains metaphase cortical tension and inactivates the spindle assembly checkpoint at anaphase
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-08957-w
Abstract: Animal cells undergo rapid rounding during mitosis, ensuring proper chromosome segregation, during which an outward rounding force abruptly increases upon prometaphase entry and is maintained at a constant level during metaphase. Initial cortical tension is… read more here.
Keywords: cortical tension; spindle assembly; cdk1 mediated; tension ... See more keywords
Artificially decreasing cortical tension generates aneuploidy in mouse oocytes
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-15470-y
Abstract: Human and mouse oocytes’ developmental potential can be predicted by their mechanical properties. Their development into blastocysts requires a specific stiffness window. In this study, we combine live-cell and computational imaging, laser ablation, and biophysical… read more here.
Keywords: cortical tension; mouse oocytes; artificially decreasing; decreasing cortical ... See more keywords
Adhesion forces and cortical tension couple cell proliferation and differentiation to drive epidermal stratification
Sign Up to like & getrecommendations! Published in 2017 at "Nature Cell Biology"
DOI: 10.1038/s41556-017-0005-z
Abstract: To establish and maintain organ structure and function, tissues need to balance stem cell proliferation and differentiation rates and coordinate cell fate with position. By quantifying and modelling tissue stress and deformation in the mammalian… read more here.
Keywords: cortical tension; adhesion; proliferation; differentiation ... See more keywords
Proteomic analysis of the actin cortex in interphase and mitosis
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cell Science"
DOI: 10.1242/jcs.259993
Abstract: In animal cells, many shape changes are driven by gradients in the contractile tension of the actomyosin cortex, a thin cytoskeletal network that supports the plasma membrane. Elucidating how cortical tension is controlled is thus… read more here.
Keywords: cell; interphase mitosis; cortical tension; tension ... See more keywords
Artificially Increasing Cortical Tension Improves Mouse Oocytes Development by Attenuating Meiotic Defects During Vitrification
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.876259
Abstract: Oocyte cryopreservation demonstrates great benefits in the conservation of animal germplasm resources and assisted reproductive technology. However, vitrification causes damages in oocytes, which would lead to the decrease of oocyte quality, and embryonic development post… read more here.
Keywords: increasing cortical; cortical tension; vitrification; development ... See more keywords
Cortical tension regulates desmosomal morphogenesis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.946190
Abstract: Mechanical stability is a fundamental and essential property of epithelial cell sheets. It is in large part determined by cell-cell adhesion sites that are tightly integrated by the cortical cytoskeleton. An intimate crosstalk between the… read more here.
Keywords: cortical tension; tension regulates; protein turnover; desmosomal protein ... See more keywords