Variant-specific changes in RAC3 function disrupt corticogenesis in neurodevelopmental phenotypes
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DOI: 10.1093/brain/awac106
Abstract: Abstract Variants in RAC3, encoding a small GTPase RAC3 which is critical for the regulation of actin cytoskeleton and intracellular signal transduction, are associated with a rare neurodevelopmental disorder with structural brain anomalies and facial… read more here.
Keywords: brain; variant specific; corticogenesis; rac3 variants ... See more keywords
Benchmarking brain organoid recapitulation of fetal corticogenesis
Sign Up to like & getrecommendations! Published in 2022 at "Translational Psychiatry"
DOI: 10.1101/2022.04.22.488753
Abstract: Brain organoids are becoming increasingly relevant to dissect the molecular mechanisms underlying psychiatric and neurological conditions. The in vitro recapitulation of key features of human brain development affords the unique opportunity of investigating the developmental… read more here.
Keywords: fetal corticogenesis; brain; corticogenesis; recapitulation ... See more keywords