Neuroprotective activity of natural products isolated from Senecio graciliflorus DC against corticosterone-induced impairment in SH-SY5Y cells.
Sign Up to like & getrecommendations! Published in 2021 at "Naunyn-Schmiedeberg's archives of pharmacology"
DOI: 10.1007/s00210-021-02136-9
Abstract: Senecio graciliflorus DC root extract was studied for secondary metabolite composition following the bioactivity-guided isolation technique. The ethyl acetate extract of Senecio graciliflorus root yielded nine chemical constituents: 3,4-di-tert-butyl toluene, stigmasterol, β-sitosterol, 2β-(angeloyloxy)furanoeremophilane, gallic acid,… read more here.
Keywords: corticosterone induced; graciliflorus; natural products; senecio graciliflorus ... See more keywords
d-Limonene protects PC12 cells against corticosterone-induced neurotoxicity by activating the AMPK pathway.
Sign Up to like & getrecommendations! Published in 2019 at "Environmental toxicology and pharmacology"
DOI: 10.1016/j.etap.2019.05.001
Abstract: The stress-induced hormone corticosterone initiates oxidative stress and inflammatory responses, culminating in cell apoptosis and neurological changes. We assessed the effects of d-Limonene on a PC12 cellular model of corticosterone-induced neurotoxicity, and whether these effects… read more here.
Keywords: corticosterone; limonene; corticosterone induced; ampk pathway ... See more keywords
Riparin II ameliorates corticosterone-induced depressive-like behavior in mice: Role of antioxidant and neurotrophic mechanisms
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DOI: 10.1016/j.neuint.2018.07.007
Abstract: &NA; Riparin II (RIP II) is an alkamide isolated from Aniba riparia that has presented antidepressant and anxiolytic effects in acute stress behavioral models. This study aimed to investigate the activity of RIP II in… read more here.
Keywords: corticosterone induced; corticosterone; like behavior; depressive like ... See more keywords
Thioredoxin interacting protein drives astrocytic glucose hypometabolism in corticosterone-induced depressive state.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of neurochemistry"
DOI: 10.1111/jnc.15489
Abstract: Brain energetics disturbance is a hypothesized cause of depression. Glucose is the predominant fuel of brain energy metabolism, however, the cell-specific change of glucose metabolism and underlying molecular mechanism in depression remain unclear. In this study, we firstly… read more here.
Keywords: glucose hypometabolism; depression; corticosterone induced; corticosterone ... See more keywords