Gamma knife radiosurgery in patients with Cushing’s disease: Comparison of aggressive pituitary corticotroph tumor versus corticotroph adenoma
Sign Up to like & getrecommendations! Published in 2020 at "Clinical Neurology and Neurosurgery"
DOI: 10.1016/j.clineuro.2020.106151
Abstract: Aggressive pituitary corticotroph tumors causing Cushing's disease are rare, and there is limited data about their clinical management. Here, we aimed to report our long-term experience with gamma knife radiosurgery (GKRS) as adjuvant treatment in… read more here.
Keywords: cushing disease; aggressive pituitary; pituitary corticotroph; corticotroph tumors ... See more keywords
O-linked β-N-acetylglucosamine transferase is involved in pro-opiomelanocortin gene expression in mouse pituitary corticotroph AtT-20 cells
Sign Up to like & getrecommendations! Published in 2019 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2019.134407
Abstract: Glucocorticoids and glucocorticoid receptors (GRs) suppress pituitary pro-opiomelanocortin (Pomc) gene expression. O-linked β-N-acetylglucosamine (O-GlcNAc) modification, mediated by O-GlcNAc transferase (OGT), plays an important role during gene transcription. However, whether OGT is involved in the GR-mediated… read more here.
Keywords: gene expression; pro opiomelanocortin; expression; corticotroph ... See more keywords
MON-406 Two Cases of Aggressive Corticotroph Pituitary Tumors Treated with Capecitabine and Temozolomide
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the Endocrine Society"
DOI: 10.1210/js.2019-mon-406
Abstract: Abstract Introduction: Aggressive corticotroph tumors exhibit continued growth despite multimodal therapy, including surgeries, radiotherapy and/or medical treatment. Temozolomide (TMZ), an oral alkylating agent, has been used to treat aggressive pituitary tumors; however, most patients only… read more here.
Keywords: therapy; corticotroph; corticotroph pituitary; surgery ... See more keywords
Single Cell RNA Sequencing in Silent Corticotroph Tumors Confirms Impaired POMC Processing and Provides New Insights into Their Invasive Behavior.
Sign Up to like & getrecommendations! Published in 2022 at "European journal of endocrinology"
DOI: 10.1530/eje-21-1183
Abstract: OBJECTIVE Provide insights into the defective POMC processing and invasive behavior in silent pituitary corticotroph tumors. DESIGN AND METHODS Single cell RNAseq was used to compare the cellular makeup and transcriptome of silent and active… read more here.
Keywords: cell; corticotroph tumors; corticotroph; silent corticotroph ... See more keywords
The Genomic Landscape of Corticotroph Tumors: From Silent Adenomas to ACTH-Secreting Carcinomas
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23094861
Abstract: Corticotroph cells give rise to aggressive and rare pituitary neoplasms comprising ACTH-producing adenomas resulting in Cushing disease (CD), clinically silent ACTH adenomas (SCA), Crooke cell adenomas (CCA) and ACTH-producing carcinomas (CA). The molecular pathogenesis of… read more here.
Keywords: acth; adenomas acth; genomic landscape; acth producing ... See more keywords
Immunotherapy in Corticotroph and Lactotroph Aggressive Tumors and Carcinomas: Two Case Reports and a Review of the Literature
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Personalized Medicine"
DOI: 10.3390/jpm10030088
Abstract: Once temozolomide has failed, no other treatment is recommended for pituitary carcinomas and aggressive pituitary tumors. Recently, the use of immune checkpoint inhibitors (ICIs) has raised hope, but so far, only one corticotroph carcinoma and… read more here.
Keywords: literature; case; pituitary mass; corticotroph carcinoma ... See more keywords