USP8 mutations in corticotroph adenomas determine a distinct gene expression profile irrespective of functional tumour status.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of endocrinology"
DOI: 10.1530/eje-19-0194
Abstract: Objective Pituitary corticotroph adenomas commonly cause Cushing's disease (CD) but part of these tumours are hormonally inactive (silent corticotroph adenomas, SCA). USP8 mutations are well known driver mutations in corticotrophinomas. Differences in transcriptomic profiles between… read more here.
Keywords: expression; status; gene expression; corticotroph adenomas ... See more keywords
Quantitative Ubiquitinomics Revealed Abnormal Ubiquitinated ATP7A Involved in Down-Regulation of ACTH in Silent Corticotroph Adenomas
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2022.863017
Abstract: Ubiquitination is reported to be a critical biological event on ACTH secretion in corticotroph adenomas. However, the effect of ubiquitylation on ACTH secretion in silent corticotroph adenomas (SCAs) remains unclear. The aim of our study… read more here.
Keywords: ubiquitinated proteins; corticotroph adenomas; secretion; silent corticotroph ... See more keywords
Transsphenoidal Surgery of Corticotroph Adenomas With Cavernous Sinus Invasion: Results in a Series of 86 Consecutive Patients
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DOI: 10.3389/fonc.2022.810234
Abstract: Objective Transsphenoidal surgery (TSS) is the first-line treatment for corticotroph adenomas. Although most corticotroph adenomas are noninvasive microadenomas, a small subset of them invading cavernous sinus (CS) is notoriously difficult to manage. The aim of… read more here.
Keywords: corticotroph adenomas; surgery; remission; cavernous sinus ... See more keywords
An Update on Silent Corticotroph Adenomas: Diagnosis, Mechanisms, Clinical Features, and Management
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DOI: 10.3390/cancers13236134
Abstract: Simple Summary The 2017 World Health Organization classification of endocrine tumors defines pituitary adenomas based on their cell lineages. T-PIT can serve as a complimentary tool for further identification of silent corticotroph adenomas (SCAs). Unlike… read more here.
Keywords: silent corticotroph; clinical features; corticotroph adenomas; scas ... See more keywords