Involvement of histone deacetylase 1/2 in adrenocorticotropic hormone synthesis and proliferation of corticotroph tumor AtT-20 cells
Sign Up to like & getrecommendations! Published in 2021 at "Peptides"
DOI: 10.1016/j.peptides.2020.170441
Abstract: Cushing's disease is mainly caused by autonomous production of adrenocorticotropic hormone (ACTH) from pituitary adenomas. In our previous study, a histone deacetylase (HDAC) inhibitor, trichostatin A, inhibited cell proliferation and ACTH production via decreased pituitary… read more here.
Keywords: cell proliferation; mrna levels; proliferation; pttg1 ... See more keywords
PI3K Inhibition by BKM120 Results in Antiproliferative Effects on Corticotroph Tumor Cells
Sign Up to like & getrecommendations! Published in 2021 at "Journal of the Endocrine Society"
DOI: 10.1210/jendso/bvab048.1116
Abstract: Abstract Purpose: Cushing’s disease is associated with significant morbidity, thus additional tumor-directed drugs with the potential to exert antineoplastic effects on corticotroph adenoma cells are desired. The PI3K (phosphoinositide-3-kinase)/AKT (protein kinase B) pathway, which plays… read more here.
Keywords: tumor; tumor cells; inhibition; corticotroph tumor ... See more keywords
Ubiquitin-specific protease 8 inhibitor suppresses adrenocorticotropic hormone production and corticotroph tumor cell proliferation.
Sign Up to like & getrecommendations! Published in 2019 at "Endocrine journal"
DOI: 10.1507/endocrj.ej19-0239
Abstract: Cushing's disease is primarily caused by autonomic hypersecretion of adrenocorticotropic hormone (ACTH) from a pituitary adenoma. In Cushing's disease, mutations in the ubiquitin-specific protease 8 (USP8) have been detected. These mutations are associated with hyperactivation… read more here.
Keywords: cell proliferation; cushing disease; cell; corticotroph tumor ... See more keywords
Effects of tubastatin A on adrenocorticotropic hormone synthesis and proliferation of AtT-20 corticotroph tumor cells.
Sign Up to like & getrecommendations! Published in 2022 at "Endocrine journal"
DOI: 10.1507/endocrj.ej21-0778
Abstract: Cushing's disease is an endocrine disorder characterized by hypercortisolism, mainly caused by autonomous production of ACTH from pituitary adenomas. Autonomous ACTH secretion results in excess cortisol production from the adrenal glands, and corticotroph adenoma cells… read more here.
Keywords: tumor; tumor cells; att corticotroph; proliferation ... See more keywords
Corticotroph tumor progression speed after adrenalectomy.
Sign Up to like & getrecommendations! Published in 2022 at "European journal of endocrinology"
DOI: 10.1530/eje-22-0536
Abstract: OBJECTIVES After bilateral adrenalectomy in Cushing's disease, corticotroph tumor progression occurs in one third to half of patients. However, progression speed is variable, ranging from slow to rapid. The aim was to explore corticotroph progression… read more here.
Keywords: adrenalectomy; progression; corticotroph tumor; progression speed ... See more keywords
New Insights in Cushing Disease Treatment With Focus on a Derivative of Vitamin A
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DOI: 10.3389/fendo.2018.00262
Abstract: Cushing’s disease (CD) is an endocrine disorder originated by a corticotroph tumor. It is linked with high mortality and morbidity due to chronic hypercortisolism. Treatment goals are to control cortisol excess and achieve long-term remission,… read more here.
Keywords: cushing disease; treatment; corticotroph tumor; vitamin ... See more keywords
Case Report: Progression of a Silent Corticotroph Tumor to an Aggressive Secreting Corticotroph Tumor, Treated by Temozolomide. Changes in the Clinic, the Pathology, and the β-Catenin and α-SMA Expression
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2022.870172
Abstract: Clinically silent corticotroph tumors are usually macroadenomas that comprise 20% of ACTH tumors. They frequently progress to aggressive tumors with high recurrence, invasiveness, and on rare occasions, they may become hormonally active causing Cushing’s disease.… read more here.
Keywords: corticotroph tumor; tumor; catenin; pathology ... See more keywords