Influence of antigen density and immunosuppressive factors on tumor-targeted costimulation with antibody-fusion proteins and bispecific antibody-mediated T cell response
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Immunology, Immunotherapy"
DOI: 10.1007/s00262-020-02624-6
Abstract: Target expression heterogeneity and the presence of an immunosuppressive microenvironment can hamper severely the efficiency of immunotherapeutic approaches. We have analyzed the potential to encounter and overcome such conditions by a combinatory two-target approach involving… read more here.
Keywords: antibody; costimulation; immunosuppressive factors; expression ... See more keywords
Costimulation Blockade in Kidney Transplant Recipients
Sign Up to like & getrecommendations! Published in 2019 at "Drugs"
DOI: 10.1007/s40265-019-01226-6
Abstract: Costimulation between T cells and antigen-presenting cells is essential for the regulation of an effective alloimmune response and is not targeted with the conventional immunosuppressive therapy after kidney transplantation. Costimulation blockade therapy with biologicals allows… read more here.
Keywords: kidney transplant; transplant recipients; costimulation blockade; costimulation ... See more keywords
Evaluation of switch-mediated costimulation in trans on universal CAR-T cells (UniCAR) targeting CD123-positive AML
Sign Up to like & getrecommendations! Published in 2021 at "Oncoimmunology"
DOI: 10.1080/2162402x.2021.1945804
Abstract: ABSTRACT Chimeric antigen receptor T cells (CAR-T) targeting CD19 have achieved significant success in patients with B cell malignancies. To date, implementation of CAR-T in other indications remains challenging due to the lack of truly… read more here.
Keywords: targeting cd123; costimulation; aml; universal car ... See more keywords
Inhibition of mevalonate metabolism by statins augments the immunoregulatory phenotype of vascular endothelial cells and inhibits the costimulation of CD4+ T cells
Sign Up to like & getrecommendations! Published in 2021 at "American Journal of Transplantation"
DOI: 10.1111/ajt.16872
Abstract: The statin family of therapeutics is widely used clinically as cholesterol lowering agents, and their effects to target intracellular mevalonate production is a key mechanism of action. In this study, we performed full transcriptomic RNA… read more here.
Keywords: mevalonate metabolism; costimulation; immunoregulatory phenotype; metabolism ... See more keywords
Corticosteroids and methotrexate as adjuvants to costimulation blockade in non‐human primate renal transplantation
Sign Up to like & getrecommendations! Published in 2019 at "Clinical Transplantation"
DOI: 10.1111/ctr.13568
Abstract: Belatacept, the CD28‐B7 costimulation pathway inhibitor, has been approved as a calcineurin inhibitor (CNI) alternative in kidney transplantation. Although costimulation blockade (CoB) allows for CNI avoidance, it is associated with increased rates of early rejection,… read more here.
Keywords: kidney transplantation; costimulation blockade; transplantation; costimulation ... See more keywords
Cancer cell-intrinsic resistance to BiTE therapy is mediated by loss of CD58 costimulation and modulation of the extrinsic apoptotic pathway
Sign Up to like & getrecommendations! Published in 2022 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2021-004348
Abstract: Background Bispecific T-cell engager (BiTE) molecules induce redirected lysis of cancer cells by T cells and are an emerging modality for solid tumor immunotherapy. While signs of clinical activity have been demonstrated, efficacy of T-cell… read more here.
Keywords: cell; loss; bite therapy; costimulation ... See more keywords
Keratinocyte-induced costimulation of human T cells through CD6 - but not CD2 - activates mTOR and prevents oxidative stress
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1016112
Abstract: In psoriasis and other inflammatory skin diseases, keratinocytes (KCs) secrete chemokines that attract T cells, which, in turn, cause epidermal hyperplasia by secreting proinflammatory cytokines. To date, it remains unclear whether skin-homing T cells, particularly… read more here.
Keywords: skin; costimulation; oxidative stress; cd6 cd2 ... See more keywords
Alternative splicing of apoptosis genes promotes human T cell survival
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.7554/elife.80953
Abstract: Alternative splicing occurs in the vast majority of human genes, giving rise to distinct mRNA and protein isoforms. We, and others, have previously identified hundreds of genes that change their isoform expression upon T cell… read more here.
Keywords: splicing apoptosis; cell; splicing events; alternative splicing ... See more keywords